Table 2

Likelihood of still being alive two years after diagnosis, by SEP, adjusted for selected patient, tumour and system factors, for full cohort

Variable	Adjusted—IMD, age, sex, histology, year, CCI, timely GP referral (n=22 967, R²=5.77)				Adjusted—IMD, age, sex, histology, year, CCI, timely GP referral, stage, PS (n=22 967, R²=12.31)				Adjusted—IMD, age, sex, histology, year, CCI, timely GP referral, stage, PS, treatment (n=22 967, R²=27.97)				Adjusted—IMD, age, sex, histology, year, CCI, timely GP referral, stage, PS, treatment, timely 1^st treatment (n=22 967, R²=28.74)
Variable	OR	95% CI		p Value	OR	95% CI		p Value	OR	95% CI		p Value	OR	95% CI		p Value
Deprivation quintile				<0.001				0.002				0.345				0.336
1 (least deprived)	1.00				1.00				1.00				1.00
2	0.87	0.76	1.00	0.054	0.87	0.76	1.01	0.073	0.88	0.75	1.04	0.130	0.88	0.75	1.04	0.137
3	0.86	0.75	0.98	0.026	0.87	0.75	1.00	0.054	0.90	0.77	1.06	0.222	0.90	0.76	1.05	0.180
4	0.80	0.70	0.91	0.001	0.83	0.72	0.95	0.005	0.94	0.81	1.09	0.410	0.94	0.81	1.09	0.394
5 (most deprived)	0.74	0.66	0.84	<0.001	0.77	0.68	0.88	<0.001	0.87	0.75	1.00	0.056	0.87	0.75	1.00	0.053
Age group (years)				<0.001				<0.001				0.115				0.040
<60	1.00				1.00				1.00				1.00
60–69	0.93	0.83	1.03	0.168	0.92	0.82	1.03	0.140	1.04	0.91	1.18	0.601	1.02	0.89	1.16	0.801
70–79	0.65	0.58	0.73	<0.001	0.64	0.57	0.71	<0.001	0.94	0.82	1.07	0.334	0.90	0.79	1.03	0.121
80+	0.35	0.31	0.41	<0.001	0.34	0.30	0.39	<0.001	0.88	0.74	1.03	0.119	0.84	0.71	1.00	0.048
Sex				<0.001				<0.001				<0.001				<0.001
Female	1.00				1.00				1.00				1.00
Male	0.74	0.69	0.80	<0.001	0.73	0.67	0.79	<0.001	0.72	0.66	0.79	<0.001	0.71	0.65	0.78	<0.001
Histology				<0.001				<0.001				<0.001				<0.001
NSCLC	1.00				1.00				1.00				1.00
SCLC	0.34	0.30	0.40	<0.001	0.36	0.31	0.42	<0.001	0.46	0.40	0.54	<0.001	0.57	0.49	0.67	<0.001
Other	0.60	0.55	0.66	<0.001	0.64	0.58	0.71	<0.001	1.28	1.14	1.44	<0.001	1.33	1.18	1.50	<0.001
Year of Diagnosis				0.082				0.204				0.009				0.009
2006	1.00				1.00				1.00				1.00
2007	1.06	0.95	1.18	0.301	1.05	0.94	1.18	0.351	1.02	0.90	1.15	0.765	1.00	0.88	1.13	0.954
2008	1.06	0.95	1.19	0.274	1.08	0.96	1.21	0.183	1.08	0.95	1.23	0.221	1.02	0.90	1.16	0.753
2009	1.19	1.04	1.36	0.010	1.16	1.01	1.33	0.036	0.83	0.71	0.98	0.025	0.80	0.68	0.93	0.005
Comorbidity score				0.007				0.011				<0.001				<0.001
0	1.00				1.00				1.00				1.00
1–2	0.95	0.83	1.09	0.503	0.94	0.81	1.08	0.376	1.10	0.93	1.29	0.253	1.10	0.93	1.29	0.253
3+	0.84	0.66	1.07	0.158	0.79	0.61	1.03	0.077	0.96	0.72	1.28	0.787	0.96	0.72	1.29	0.807
Missing	0.82	0.74	0.92	<0.001	0.83	0.74	0.93	0.001	0.84	0.73	0.95	0.006	0.83	0.73	0.95	0.006
Unavailable	0.94	0.82	1.07	0.324	0.97	0.85	1.11	0.659	1.37	1.17	1.60	<0.001	1.38	1.18	1.61	<0.001
Timely GP referral				<0.001				<0.001				<0.001				<0.001
No GP referral date	1.00				1.00				1.00				1.00
FHA≤14 days	1.44	1.32	1.58	<0.001	1.40	1.28	1.53	<0.001	1.16	1.05	1.29	0.004	1.14	1.03	1.26	0.015
FHA>14 days	1.98	1.79	2.19	<0.001	1.80	1.62	2.01	<0.001	1.40	1.25	1.58	<0.001	1.36	1.20	1.53	<0.001
Stage								<0.001				<0.001				<0.001
I					1.00				1.00				1.00
II					0.38	0.29	0.50	<0.001	0.48	0.35	0.68	<0.001	0.49	0.35	0.69	<0.001
III					0.13	0.11	0.16	<0.001	0.29	0.23	0.36	<0.001	0.30	0.24	0.38	<0.001
IV					0.04	0.03	0.05	<0.001	0.12	0.09	0.15	<0.001	0.13	0.10	0.17	<0.001
Missing					0.17	0.14	0.20	<0.001	0.31	0.25	0.38	<0.001	0.33	0.27	0.41	<0.001
Performance status								<0.001				0.001
0					1.00				1.00				1.00
1–2					0.55	0.47	0.65	<0.001	0.88	0.73	1.05	0.157	0.89	0.74	1.07	0.201
3–4					0.18	0.14	0.24	<0.001	0.59	0.43	0.81	0.001	0.61	0.44	0.83	0.002
Missing					0.45	0.38	0.54	<0.001	0.73	0.60	0.90	0.002	0.72	0.59	0.88	0.002
Type of treatment												<0.001				<0.001
No treatment									1.00				1.00
Surgery									49.77	41.93	59.07	<0.001	60.95	51.12	72.66	<0.001
Surgery + chemotherapy and/or radiotherapy									33.00	26.99	40.34	<0.001	40.47	32.96	49.69	<0.001
Chemotherapy									3.25	2.71	3.91	<0.001	4.19	3.47	5.05	<0.001
Chemotherapy + radiotherapy									7.83	6.65	9.22	<0.001	10.03	8.48	11.86	<0.001
Radiotherapy									3.34	2.89	3.87	<0.001	4.12	3.55	4.78	<0.001
Timely 1st treatment																<0.001
>31 days from diagnosis													1.00
<31 days from diagnosis													0.50	0.45	0.56	<0.001

CCI score, Charlson Comorbidity Score; FHA, first hospital appointment; IMD, Index of Multiple Deprivation; NSCLC, non-small cell lung cancer; SCLC, small cell lung cancer.