Adjusted incidence predictions for lung cancer and COPD as a function of serum uric acid levels showing an interaction with smoking status
| Serum uric acid quintiles (µmol/L) | |||||
|---|---|---|---|---|---|
| 100–250 | 251–307 | 308–360 | 361–437 | 438–700 | |
| n=42 435 | n=39 874 | n=41 273 | n=40 866 | n=41 036 | |
| Predicted incidence of lung cancer per 10 000 PYs (95% CI)* | |||||
| Non-smoker | 3.0 (1.9 to 4.1) | 3.0 (2.3 to 3.7) | 3.0 (2.4 to 3.6) | 3.0 (2.4 to 3.7) | 3.1 (1.7 to 4.4) |
| Ex-smoker | 11.2 (9.0 to 13.4) | 11.8 (10.4 to 13.3) | 12.2 (10.9 to 13.4) | 12.6 (11.4 to 13.9) | 13.8 (11.3 to 16.4) |
| Light-moderate | 45.9 (34.2 to 57.7) | 40.2 (33.7 to 46.7) | 37.5 (32.0 to 43.0) | 34.5 (28.5 to 40.5) | 27.8 (18.0 to 37.5) |
| Heavy | 97.0 (67.8 to 126.3) | 69.6 (56.1 to 83.1) | 58.4 (47.3 to 69.4) | 47.4 (36.0 to 58.8) | 27.5 (14.2 to 40.9) |
| Predicted incidence of COPD per 10 000 PYs (95% CI)* | |||||
| Non-smoker | 16.6 (14.0 to 19.3) | 17.1 (15.3 to 18.9) | 17.4 (15.8 to 18.9) | 17.7 (15.9 to 19.4) | 18.5 (15.0 to 22.0) |
| Ex-smoker | 49.5 (44.0 to 54.9) | 51.4 (47.4 to 55.4) | 52.4 (48.9 to 56.0) | 53.7 (50.1 to 57.3) | 57.2 (50.9 to 63.4) |
| Light-moderate | 167.3 (144.1 to 190.5) | 147.1 (133.3 to 160.8) | 137.4 (125.3 to 149.4) | 126.7 (113.8 to 139.6) | 102.6 (82.7 to 122.6) |
| Heavy | 247.7 (206.6 to 288.8) | 213.2 (189.6 to 236.7) | 196.9 (176.5 to 217.4) | 179.3 (157.3 to 201.3) | 140.3 (106.8 to 173.8) |
The median (middle) value of serum uric acid within each quintile was used as the fixed value for the prediction.
*Adjusted for age, sex, social deprivation, year of uric acid test, alcohol, height, weight, blood pressure, non-European ethnicity and particle pollution.
PYs, person years.