Comparison of response to pulmonary rehabilitation between sarcopenic and propensity-matched patients with non-sarcopenic COPD expressed as mean (95% CI)
| Baseline | Change with PR | |||||
|---|---|---|---|---|---|---|
| Non-sarcopenic | Sarcopenic | p Value | Non-sarcopenic | Sarcopenic | p Value | |
| Mean age (years (SD))* | 72 (11) | 73 (8) | 0.733 | – | – | – |
| Gender* (M:F) | 25:18 | 28:15 | 0.508 | – | – | – |
| FEV1% predicted* | 45.1 (39.2 to 51.0) | 43.5 (37.4 to 50.2) | 0.728 | – | – | – |
| MRC* | 3 (3.3 to 3.9) | 3 (3.0 to 3.6) | 0.275 | −0.8 (−1.1 to −0.5) | −0.7 (−1.0 to −0.3) | 0.495 |
| Weight (kg) | 77.3 (77.0 to 81.4) | 57.9 (53.9 to 62.2) | <0.001 | 0.0 (−0.6 to 0.6) | −0.1 (−0.5 to 0.3) | 0.616 |
| BMI (kg/m) | 28.7 (27.3 to 30.0) | 21.3 (20.1 to 22.5) | <0.001 | 0.0 (−0.3 to 0.2) | 0.0 (−0.3 to 0.1) | 0.723 |
| SMM (kg) | 23.9 (22.1 to 25.6) | 19.1 (17.6 to 20.7) | <0.001 | 0.1 (−0.3 to 0.5) | 0.3 (0.0 to 0.7) | 0.363 |
| SMI (kg/m2) | 8.8 (8.3 to 9.3) | 7.0 (6.6 to 7.3) | <0.001 | 0.0 (−0.1 to 0.2) | 0.1 (0.0 to 0.2) | 0.431 |
| Handgrip (kg) | 25.7 (22·8 to 28.4) | 21.2 (19.2 to 23.3) | 0.021 | 1.6 (0.5 to 2.6) | 2.1 (1.3 to 2.9) | 0.516 |
| QMVC (kg) | 25.7 (23.0 to 28.3) | 19.9 (17.9 to 22.3) | 0.003 | 0.9 (−1.1 to 3.5) | 1.4 (0.3 to 3.7) | 0.646 |
| QMVC % predicted | 60.0 (55.3 to 64.4) | 55.1 (50.1 to 60.3) | 0.164 | 1.1 (−3.7 to 6.5) | 3.8 (0.4 to 9.8) | 0.574 |
| 4MGS (m/s) | 0.86 (0.80 to 0.91) | 0.83 (0.77 to 0.89) | 0.511 | 0.11 (0.07 to 0.14) | 0.12 (0.08 to 0.16) | 0.552 |
| 5STS (s) | 15.5 (13.6 to 18.4) | 18.1 (13.2 to 28.8) | 0.186 | −2.9 (−4.1 to −1.6) | −1.7 (−3.9 to 0.0) | 0.517 |
| SPPB | 9 (8.4 to 9.8) | 9 (8.0 to 9.4) | 0.386 | 1.0 (10.51 to 1.5) | 0.9 (0.4 to 1.4) | 0.746 |
| ISWT (m)* | 168 (139 to 197) | 194 (158 to 232) | 0.284 | 40 (30 to 60) | 50 (40 to 80) | 0.214 |
| CAT | 20.0 (17.5 to 22.2) | 23.8 (21.3 to 26.4) | 0.031 | −3.0 (−4.4 to −1.5) | −4.7 (−6.9 to −2.3) | 0.236 |
| SGRQ | ||||||
| Symptoms | 64.6 (58.3 to 70.9) | 68.5 (63.5 to 74.1) | 0.360 | −9.7 (−17.3 to −2.4) | −7.85 (−12.0 to −3.6) | 0.675 |
| Activity | 71.8 (64.6 to 79.1) | 73.7 (68.4 to 78.9) | 0.685 | −5.7 (−10.4 to −1.5) | −5.66 (−10.7 to −0.4) | 0.994 |
| Impact | 38.1 (32.0 to 44.5) | 39.9 (34.3 to 45.7) | 0.668 | −7.9 (12.0 to −3.7) | −7.27 (−10.8 to −3.7) | 0.821 |
| Total | 52.7 (47.3 to 58.4) | 54.9 (50.1 to 60.1) | 0.570 | −6.3 (−9.5 to −3.0) | −6.81 (−10.1 to −3.4) | 0.836 |
*Variable used for propensity score.
4MGS, 4-metre gait speed; 5STS, five-repetition sit-to-stand test; BMI, Body Mass Index; CAT, COPD Assessment Test; ISWT, incremental shuttle walk test; MRC, Medical Research Council; PR, pulmonary rehabilitation; SGRQ, St George's Respiratory Disease Questionnaire; SMI, Skeletal Muscle Mass Index; SMM, skeletal muscle mass; SPPB, short physical performance battery; QMVC, quadriceps maximum voluntary contraction.