Serum measures of kidney and liver function, glucose and lactate in the three groups of sheep at baseline, 12 and 24 h
| Parameter | Group | Baseline | 12 | 24 |
|---|---|---|---|---|
| Blood urea nitrogen | Control | 13±1 | 11±2 | 15±4 |
| Lower dose | 13±1 | 14±2 | 13±1 | |
| Higher dose | 16±4 | 14±3 | 10±2 | |
| Creatinine | Control | 0.6±0.0 | 0.7±0.1 | 0.9±0.1 |
| Lower dose | 0.7±0.0 | 1.0±0.2 | 0.9±0.2 | |
| Higher dose | 0.7±0.0 | 0.8±0.1 | 0.7±0.1 | |
| Alanine transaminase | Control | 46±4 | 40±2 | 39±3 |
| Lower dose | 46±7 | 42±6 | 39±5 | |
| Higher dose | 57±7 | 53±6 | 43±6 | |
| Aspartate aminotransferase | Control | 177±20 | 160±24 | 187±22 |
| Lower dose | 161±27 | 135±23 | 140±16* | |
| Higher dose | 200±26 | 195±33 | 143±12 | |
| Glucose | Control | 70±4 | 38±5 | 37±4 |
| Lower dose | 65±3 | 45±4 | 34±2 | |
| Higher dose | 59±6 | 35±3 | 33±4 | |
| Lactate | Control | 0.5±0.1 | 3.7±1.3 | 2.2±0.7 |
| Lower dose | 0.3±0.0 | 3.2±0.6 | 2.4±1.0 | |
| Higher dose | 0.4±0.1 | 2.8±1.0 | 1.4±0.1 |
Data are expressed as±SEM. No differences at baseline by one-way ANOVA, and at 12 h and 24 h by ANCOVA among three groups except indicated. Baseline: n=8 for control; n=7 for lower dose; n=4 for higher dose. T=12 h: n=8 for control; n=6 for lower dose; n=4 for higher dose. T=24 h: n=6 for control; n=6 for lower dose; n=3 for higher dose.
*p=0.03 by ANCOVA compared with control group.