Estimate (95% CI) of effect of maternal asthma, flow limitation, infant atopy, maternal smoking and male sex on measurements of lung function (maximal flow at functional residual capacity in infancy, V'maxFRC and FEF25–75 in childhood) made between ages 1 month and 18 years
| Effect size (95% CIs) on percentage of predicted lung function measurements made between 1 month and 18 years | p Value for interaction term with time | ||||||
|---|---|---|---|---|---|---|---|
| 1 month (V'maxFRC) | 6 months (V'maxFRC) | 12 months (V'maxFRC) | 6 years (FEF25–75) | 12 years (FEF25–75) | 18 years (FEF25–75) | ||
| Maternal asthma | −9.5 (−20.1 to +1.0) | −9.6 (−19.9 to +0.8) | −9.6 (−19.6 to +0.5) | −9.8 (−17.4 to −2.2) | −10.1 (−16.9 to −3.3) | −10.4 (−19.3 to −1.4) | 0.908 |
| Flow limitation | −45.2 (−60.0 to −30.5) | −44.0 (−58.3 to −29.7) | −42.5 (−56.5 to −28.6) | −27.5 (−38.0 to −17.0) | −9.4 (−19.3 to +0.6) | +8.7 (−4.9 to +22.4) | <0.001 |
| Infant atopy | −15.2 (−27.9 to −2.6) | −15.1 (−27.5 to −2.7) | −15.0 (−27.0 to −2.9) | −13.6 (−22.6 to −4.6) | −11.9 (−19.8 to −4.0) | −10.2 (−20.4 to +0.1) | 0.548 |
| Maternal smoker during pregnancy | −16.4 (−26.1 to −6.7) | −16.1 (−25.5 to −6.6) | −15.6 (−24.8 to −6.4) | −11.0 (−18.0 to −4.0) | −5.5 (−12.2 to +1.1) | −0.0 (−9.0 to +8.9) | 0.018 |
| Male Sex | −10.2 (−18.8 to −1.6) | −9.8 (−18.2 to −1.4) | −9.3 (−17.4 to −1.2) | −4.4 (−10.5 to +1.8) | +1.6 (−3.9 to +7.1) | +7.5 (+0.2 to +14.7) | 0.003 |