HR of TB by BCG vaccination and other demographic characteristics in a cohort of children and young adults in East Greenland
| Demographic characteristics | Total | TB | HR* (95% CI) | p Value† | ||
|---|---|---|---|---|---|---|
| Person-years | N | N (%) | Unadjusted estimate | Adjusted‡ estimate | ||
| All | 21 148 | 1697 | 94 (6) | |||
| BCG-vaccinated | ||||||
| No | 5471 | 419 | 47 (11) | 1 | 1 | |
| Yes | 15 676 | 1278 | 47 (4) | 0.25 (0.16 to 0.40) | 0.50 (0.26 to 0.95) | 0.03 |
| Sex | ||||||
| Female | 10 764 | 856 | 44 (5) | 1 | 1 | |
| Male | 10 383 | 841 | 50 (6) | 1.17 (0.78 to 1.77) | 1.26 (0.84 to 1.89) | 0.27 |
Ethnicity: All TB cases were among Inuits. The analysis was also done without non-Inuit, not changing the results.
Effect modification: For individuals younger than 15 years, the adjusted HR is 0.82 (95% CI 0.34 to 2.01) and for individuals 15 years or older the HR is 0.42 (95% CI 0.15 to 1.23). Test for homogeneity for effect modification by age p=0.12.
*The HRs relate to the hazard of having TB at a given age.
†Test for homogeneity based on the analysis with adjustment.
‡Adjusted for BCG, time of birth/age and stratified for sex.