Characteristics of participants included in airway dimensions analysis
| MESA COPD | SPIROMICS | |||
|---|---|---|---|---|
| No COPD N=166 | COPD N=145 | No COPD N=438 | COPD N=810 | |
| Age—year | 68±7 | 68±7 | 61±10 | 66±8 |
| Male—% | 54 | 66 | 46 | 59 |
| Race-ethnicity—% | ||||
| White | 45 | 62 | 70 | 84 |
| Black | 25 | 28 | 26 | 12 |
| Other | 30 | 10 | 5 | 5 |
| Height—cm | 167±9 | 171±9 | 170±10 | 171±10 |
| Weight—kg | 80±17 | 80±19 | 83±18 | 80±17 |
| Smoking status—% | ||||
| Former | 77 | 67 | 54 | 68 |
| Current | 23 | 33 | 46 | 32 |
| Pack-years | 32±19 | 44±32 | 43±21 | 54±25 |
| Per cent predicted FEV1 | 100±16 | 74±19 | 95±14 | 62±23 |
| FEV1/FVC | 78±5 | 58±11 | 87±5 | 51±13 |
| COPD GOLD severity—% | ||||
| Mild (FEV1≥80% predicted) | – | 39 | – | 24 |
| Moderate (50%≥FEV1<80% predicted) | – | 47 | – | 44 |
| Severe (30%≥FEV1<50% predicted) | – | 12 | – | 23 |
| Very severe (FEV1<30% predicted) | – | 1 | – | 9 |
| Lung volume at CT—L | 4.2±1.1 | 4.8±1.2 | 5.3±1.2 | 6.3±1.4 |
| Per cent emphysema−950HU—median (IQR) | 1.2 (1.8) | 4.5 (7.7) | 0.9 (1.7) | 6.9 (14) |
| No. of airways per participant—median (1st, 3rd quartile) | ||||
| Lumen diameter>11.5 mm | 2 (2, 3) | 2 (2, 3) | 2 (2, 3) | 2 (2, 3) |
| 10.0 mm<lumen diameter≤11.5 mm | 1 (1, 2) | 1 (1, 2) | 1 (1, 2) | 1 (0, 2) |
| 8.5 mm<lumen diameter≤10.0 mm | 2 (1, 2) | 2 (1, 2) | 2 (1, 3) | 2 (1, 2)* |
| 7.0 mm<lumen diameter≤8.5 mm | 3 (2, 4) | 3 (2, 3)* | 3 (2, 4) | 3 (2, 4)* |
| 5.5 mm<lumen diameter≤7.0 mm | 4 (3, 5) | 4 (2, 5)* | 3 (2, 5) | 3 (2, 4)* |
| 4.0 mm<lumen diameter≤5.5 mm | 7 (6, 10) | 7 (5, 8)* | 8 (6, 10) | 6 (4, 8)* |
| 2.5 mm<lumen diameter≤4.0 mm | 28 (20, 38) | 19 (14, 27)* | 34 (24, 44) | 20 (15, 28)* |
| Lumen diameter—mm | ||||
| Generation 0 | 16.0±2.3 | 16.5±2.6 | 16.7±2.4 | 16.4±2.5 |
| Generation 1 | 12.0±1.9 | 12.0±1.9 | 12.6±2.1 | 12.3±2.0 |
| Generation 2 | 8.5±1.6 | 8.4±1.6 | 8.8±1.5 | 8.6±1.6 |
| Generation 3 | 6.1±1.5 | 5.7±1.5* | 6.3±1.6 | 6.0±1.6* |
| Generation 4 | 4.4±1.4 | 4.1±1.3* | 4.7±1.7 | 4.3±1.5* |
| Generation 5 | 3.2±1.0 | 3.0±1.0* | 3.4±1.0 | 3.1±1.0* |
| Generation 6 | 2.6±0.9 | 2.5±1.0* | 2.7±0.9 | 2.5±0.8* |
Plus-minus values are means±SD.
*P<0.05 for comparison between COPD and controls of airway lumen diameter (Student t test) or number of airways per participant (Pearson's χ2-test).
GOLD, Global Initiative for chronic Obstructive Lung Disease; HU, Hounsfield units; MESA, Multi-Ethnic Study of Atherosclerosis; SPIROMICS, Subpopulations and Intermediate Outcome Measures in COPD Study.