Quantification of inflammatory cells in the lamina propria of patients with COPD, asthma, control smokers and control non-smoking subjects
| Patients | |||||||
|---|---|---|---|---|---|---|---|
| Young control | Old control | Control smokers | COPD | Old asthma | Young asthma | p Value (Kruskal-Wallis) | |
| CD4 | 104 (34–194) | 133 (63–175) | 105 (68–175) | 119 (86–139) | 180 (120–296)* | 189 (86–298) | 0.0371 |
| CD8 | 91 (64–193) | 111 (82–168) | 129 (96–214) | 196 (146–267)** | 116 (83–155) | 52 (20–111) | 0.0010 |
| CD68 | 258 (177–271) | 235 (128–370) | 299 (215–520) | 480 (273–673)*** | 226 (151–303) | 264 (214–375) | 0.0016 |
| Mast cells | 50 (47–64) | 52 (32–63) | 38 (21–73) | 75 (42–127) | 38 (28–97) | 94 (69–132) | 0.1276 |
| Neutrophils | 124 (90–140) | 88 (62–133) | 113 (84–146) | 151 (104–290)**** | 241 (147–309)**** | 195 (86–247) | 0.0006 |
| Eosinophils | 8 (0–21) | 15 (0–26) | 4 (0–21) | 6 (0–35) | 39 (35–60)* | 32 (10–115)* | 0.0002 |
Data are presented as median (lower quartile, LQ—upper quartile, UQ).
The Kruskal-Wallis test was applied for multiple comparisons. For comparison between groups the Mann-Whitney U test was applied.
The exact p values for comparison between groups are given in the Results section.
*p<0.05 significantly different from young/old controls, control smokers and patients with COPD.
**p<0.05 significantly different from old controls and young/old patients with asthma.
***p<0.05 significantly different from young/old controls, control smokers and young/old patients with asthma.
****p<0.05 significantly different from young/old controls and control smokers.
COPD, chronic obstructive pulmonary disease.