Patient demographics and clinical characteristics of the idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP) cohort by Groups I and II from figure 1
| Group I | Group II | p Value | |
|---|---|---|---|
| Number (%) | 68 (57) | 51 (43) | |
| Age—mean (SD) | 62.9 (9.6) | 62.0 (7.4) | 0.48* |
| Gender—% male | 58.8 | 72.5 | 0.56** |
| Race—% Caucasian | 97.1 | 90.2 | 0.78* |
| Smoker—N (%) | 0.74* | ||
| Current | 0 (0) | 0 (0) | |
| Former | 40 (58) | 30 (59) | |
| Never | 22 (32) | 19 (37) | |
| Unknown | 6 (10) | 2 (4) | |
| Pack years—mean (SD)† | 71.6 (117) | 67.7 (116) | 0.42* |
| St George's score—mean (SD) | 47.0 (21.3) | 48.0 (21.9) | 0.64* |
| Medication use within 30 days of biopsy‡ (%) | 0.54** | ||
| Corticosteroids | 19 (49) | 11 (43) | |
| Immunosuppressants | 11 (28) | 14 (40) | |
| Corticosteroids and immunosuppressants | 9 (23) | 6 (17) | |
| pre-BD FVC, %predicted (SD) | 62.8 (17.2) | 59.1 (16.7) | 0.97* |
| DLCO, %predicted (SD) | 45.2 (20.9) | 45.0 (19.8) | 0.98* |
| Lobe-specific honeycombing (HRCT scan)§ | 0.13** | ||
| 0-Normal/None | 15 | 15 | |
| 1-Mild (1–25%) | 16 | 10 | |
| 2-Moderate (26–50%) | 7 | 4 | |
| 3-Marked (51–75%) | 3 | 0 | |
| 4-Severe (>75%) | 1 | 5 | |
| Unknown | 26 | 17 | |
| Sum honeycombing (HRCT scan)¶ (SD) | 3.66 (6.53) | 5.00 (8.38) | 0.33* |
| Lung tissue pathology—microscopic honeycombing score | |||
| 0 (unscored/not present) | 46 | 11 | <0.0001*** |
| 1 (rare) | 5 | 10 | |
| 2 (present) | 17 | 30 | |
| Lung tissue pathology—fibroblastic foci score | |||
| 0 (unscored/not present) | 44 | 33 | 1.00*** |
| 1 (rare) | 11 | 5 | |
| 2 (present) | 13 | 13 | |
*By two-tailed t test.
**By χ2 test.
***By Fisher Exact test, test for 0 compared to combined 1 and 2 scores.
†Average for current and former smokers.
‡Information available for 74 patients.
§Extent of honeycombing in the lobe that mRNA was extracted from, as determined by high-resolution CT scan (HRCT).
¶Sum of honeycomb scores for all lobes.