Comparison of CPAP to Provent and placebo Provent
| CPAP vs Provent | CPAP vs placebo Provent | |||||||
|---|---|---|---|---|---|---|---|---|
| CPAP | Provent | Treatment effect and 95% CI | p Value | CPAP | Placebo Provent | Treatment effect and 95% CI | p Value | |
| AHI (events/h) | 2.4 (2.4) | 27.6 (16.4) | +25.2 (+18.3 to +32.2) | <0.001 | 2.4 (2.4) | 24.2 (16.8) | +21.8 (+14.7 to +29.0) | <0.001 |
| ODI (events/h) | 4.3 (5.1) | 35.8 (17.4) | +31.5 (+23.9 to +39.2) | <0.001 | 4.3 (5.1) | 28.2 (18.3) | +24.0 (+15.9 to +32.0) | <0.001 |
| Systolic BP (mm Hg) | 129.7 (11.4) | 138.0 (17.3) | +8.3 (−0.8 to +17.4) | 0.072 | 129.7 (11.4) | 135.1 (13.1) | +5.6 (−2.0 to +13.3) | 0.14 |
| Diastolic BP (mm Hg) | 79.2 (8.2) | 85.3 (8.2) | +6.1 (+1.0 to +11.2) | 0.021 | 79.2 (8.2) | 86.5 (8.2) | +7.4 (+2.3 to +12.4) | 0.006 |
| ESS | 8.0 (5.1) | 9.3 (4.8) | +1.3 (−1.8 to +4.4) | 0.40 | 8.0 (5.1) | 10.6 (3.8) | +2.6 (−0.2 to +5.5) | 0.065 |
Outcomes at 2 weeks are presented as mean (SD).
AHI, apnoea–hypopnoea index; BP, blood pressure; CPAP, continuous positive airway pressure; ESS, Epworth Sleepiness Scale; ODI, oxygen desaturation index.