Multivariate analysis of mRNA transcripts and standard outcome variables for treatment effect in cystic fibrosis (with 95% CIs)
| Variable | Sensitivity | Specificity | PPV | NPV | Accuracy |
|---|---|---|---|---|---|
| FEV1 | 74 (62 to 85) | 54 (41 to 67) | 62 (50 to 73) | 67 (54 to 81) | 64 (55 to 73) |
| CRP | 82 (73 to 92) | 53 (40 to 66) | 64 (53 to 74) | 75 (62 to 88) | 68 (59 to 76) |
| PBMC panel | 65 (53 to 78) | 73 (61 to 84) | 71 (58 to 83) | 68 (56 to 80) | 69 (60 to 78) |
| Whole blood panel (plus FEV1 (ALL)* | 77 (66 to 88) | 88 (79 to 96) | 86 (77 to 96) | 79 (69 to 89) | 82 (76 to 89) |
| Whole blood panel (plus FEV1)† | 70 (57 to 84) | 93 (86 to 100) | 91 (82 to 100) | 76 (65 to 87) | 82 (74 to 90) |
*Computed for all subjects who had whole blood panel data (57 subjects).
†Computed for all subjects who returned to baseline FEV1 at treatment end (43 subjects).
CRP, C reactive protein; FEV1, forced expiratory volume in 1 s; NPV, negative predictive value; PBMC, peripheral blood mononuclear cell; PPV, positive predictive value.