Association between ALDH1A1 and CD133 expression and clinicopathological variables for patients with non-small cell lung cancer (N=205)
| ALDH1A1 expression | CD133 | ||||||
|---|---|---|---|---|---|---|---|
| Variable | No. (%) | Low score No. (%) | High score No. (%) | p Value† | Low score No. (%) | High score No. (%) | p Value† |
| Age | |||||||
| ≤70 | 98 (47.8) | 32 (31.9) | 66 (68.1) | 0.761 | 46 (46.4) | 52 (53.6) | 0.571 |
| >70 | 107 (52.2) | 32 (29.2) | 75 (70.8) | 55 (50.9) | 52 (49.1) | ||
| Sex | |||||||
| Male | 125 (61) | 42 (33.3) | 82 (66.6) | 0.442 | 60 (47.2) | 65 (52.8) | 0.660 |
| Female | 80 (39) | 22 (26.3) | 59 (73.7) | 41 (51.2) | 39 (48.8) | ||
| Smoking | |||||||
| Yes | 182 (88) | 54 (29.4) | 128 (70.6) | 0.365 | 90 (48.9) | 92 (51.1) | 0.414 |
| No | 23 (12) | 10 (43.5) | 13 (56.5) | 11 (48) | 12 (52) | ||
| Stage | |||||||
| 1a | 144 (70) | 54 (37) | 90 (63) | 0.003* | 63 (43.4) | 81 (56.6) | 0.023* |
| 1b | 61 (30) | 10 (15) | 51 (85) | 38 (61.7) | 23 (38.3) | ||
| Histological type | |||||||
| ADC | 121 (59) | 48 (33.9) | 74 (66.1) | 0.002* | 48 (39.7) | 73 (60.3) | 0.001* |
| SCC | 84 (41) | 16 (18.3) | 67 (81.7) | 53 (62.2) | 31 (37.8) | ||
| Nodal dissection | |||||||
| <10 nodes | 121 (59) | 35 (27.6) | 86 (72.4) | 0.279 | 60 (50) | 60 (50) | 0.847 |
| ≥10 nodes | 84 (41) | 30 (36.6) | 54 (63.4) | 43 (51.6) | 42 (49.4) | ||
| Lymphatic invasion | |||||||
| Absent | 174 (85) | 55 (30.8) | 119 (69.2) | 0.841 | 86 (48.8) | 88 (51.2) | 1.000 |
| Present | 31 (15) | 9 (29) | 22 (71) | 15 (48.4) | 16 (51.6) | ||
| Vascular invasion | |||||||
| Absent | 149 (72.6) | 49 (32.7) | 100 (67.3) | 0.489 | 70 (46.3) | 79 (53.7) | 0.341 |
| Present | 56 (27.4) | 15 (25) | 42 (75) | 31 (55.4) | 25 (44.6) | ||
| Surgery type | |||||||
| Lobectomy | 178 (87) | 56 (30.7) | 122 (69.3) | 0.967 | 86 (47.7) | 92 (52.3) | 0.563 |
| Wedge resection | 23 (11) | 7 (30.4) | 16 (69.6) | 12 (52.2) | 11 (47.8) | ||
| Pneumonectomy | 4 (2) | 1 (25) | 3 (75) | 3 (75) | 1 (25) | ||
*Bold indicates statistical significance.
†χ2 test.
ADC, adenocarcinoma; ALDH1A1, aldehyde dehydrogenase 1A1; SCC, squamous cell carcinoma.