Between-group comparisons of adjusted mean (SE) data from linear mixed-model analyses
| Outcome | Discharge | 8-week follow-up | 6-month follow-up | p Value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | Control | PEP | n | Control | PEP | n | Control | PEP | ||
| BCSS | 80 | 5.0 (0.4) | 5.2 (0.4) | 78 | 4.8 (0.4) | 5.0 (0.4) | 71 | 4.5 (0.4) | 4.6 (0.4) | 0.978 |
| Group difference, mean (95% CI) | 0.2 (−0.9 to 1.4) | 0.2 (−0.9 to 1.4) | 0.1 (−1.1 to 1.3) | |||||||
| SGRQ—Total | . | . | . | 72 | 40.8 (2.8) | 41.6 (2.6) | 71 | 40.6 (2.8) | 42.1 (2.6) | 0.872 |
| Group difference, mean (95% CI) | 0.8 (−6.7 to 8.3) | 1.4 (−6.1 to 9.0) | ||||||||
| SGRQ—symptoms | . | . | . | 72 | 52.8 (3.6) | 55.8 (3.4) | 72 | 56.0 (3.5) | 58.4 (3.4) | 0.909 |
| SGRQ—activity | . | . | . | 72 | 48.9 (3.8) | 46.9 (3.6) | 71 | 46.7 (3.8) | 45.5 (3.6) | 0.899 |
| SGRQ—impact | . | . | . | 72 | 32.9 (2.8) | 34.2 (2.6) | 71 | 32.4 (2.8) | 34.9 (2.6) | 0.783 |
| BODE | 65 | 5.3 (0.5) | 5.8 (0.4) | 38 | 5.1 (0.5) | 5.2 (0.5) | 26 | 5.0 (0.6) | 5.6 (0.6) | 0.608 |
| Group difference, mean (95% CI) | 0.5 (−0.7 to 1.8) | 0.1 (−1.3 to 1.5) | 0.6 (−1.1 to 2.2) | |||||||
| BMI, kg/m2 | 76 | 26.5 (1.1) | 24.1 (1.1) | 53 | 26.2 (1.2) | 23.8 (1.1) | 38 | 23.6 (1.4) | 22.3 (1.2) | 0.711 |
| FEV1,% predicted | 71 | 35.9 (1.4) | 35.6 (1.4) | 47 | 36.6 (1.9) | 36.5 (1.6) | 32 | 37.7 (2.4) | 36.4 (1.9) | 0.941 |
| mMRC | 84 | 2.4 (0.2) | 2.8 (0.2) | 72 | 2.6 (0.2) | 2.2 (0.2) | 71 | 2.4 (0.2) | 2.9 (0.2) | 0.006 |
| 6MWD, m | 68 | 297 (23.2) | 271 (22.7) | 44 | 296 (25.1) | 324 (24.2) | 29 | 337 (29.3) | 333 (27.3) | 0.052 |
p Values represent group×time interaction effects where values<0.05 were considered statistically significant. Empty cells refer to timepoints where outcome data were not collected. Mean group differences were calculated at each timepoint from the final adjusted linear mixed model data (PEP—control).
6MWD, 6 min walk distance; BCSS, breathlessness, cough and sputum scale; BMI, body mass index; BODE, index derived from BMI, airflow Obstruction, Dyspnoea, Exercise tolerance; FEV1, forced expiratory volume in the first second; m, metres; mMRC, modified Medical Research Council dyspnoea scale; PEP, positive expiratory pressure; SGRQ, St George's Respiratory Questionnaire.