Evaluation of yield of each test individually and combinations of tests
| Approach | Number of patients identified for chemoprophylaxis (%) | Number of patients missed (would have been identified via other methods) (%) | Sensitivity versus triple combination testing (%) |
|---|---|---|---|
| Single test | |||
| Risk factor approach alone | 27 (19.7) | 39 (28.5) | 40.9 (29.0–53.7) |
| T.Spot positive alone | 25 (18.2) | 41 (29.9) | 37.9 (26.2–50.7) |
| TST positive alone | 31 (22.6) | 35 (25.5) | 47.0 (34.6–59.7) |
| Double test combinations | |||
| Risk factor and/or T.Spot positive | 48 (35.0) | 18 (13.1) | 72.7 (60.4–83.0) |
| Risk factor and/or TST positive | 53 (38.7) | 13 (9.5) | 80.3 (68.7–89.1) |
| T.Spot positive and/or TST positive | 47 (34.3) | 19 (13.9) | 71.2 (58.7–81.7) |
| Triple test combination | |||
| Risk factor and/or T.Spot positive and/or TST positive | 66 (48.2) | – | – |
Data shown as n (% of total cohort 137) or sensitivity (95% CI).
TST, tuberculin skin test.