Table 2

Relationship between maternal prepregnancy fat mass (kg) and wheeze and atopy phenotypes in the offspring at age 6 years

Unadjusted analysisModel 1Model 2
OutcomeRR(95% CI)p ValuenRR(95% CI)p ValuenRR(95% CI)p Valuen
Ever wheeze1.09(1.03 to 1.16)0.0039211.08(1.02 to 1.15)0.0078951.09(1.03 to 1.16)0.002895
Ever asthma1.10(0.93 to 1.31)0.279271.05(0.89 to 1.24)0.578901.10(0.93 to 1.30)0.28890
Current wheeze1.04(0.86 to 1.25)0.689271.06(0.87 to 1.29)0.548081.09(0.90 to 1.32)0.39808
Current asthma1.14(0.91 to 1.43)0.249271.10(0.89 to 1.37)0.399181.14(0.92 to 1.41)0.22918
Transient wheeze1.13(1.05 to 1.23)0.0027641.11(1.02 to 1.20)0.017431.12(1.03 to 1.21)0.006743
Persistent wheeze1.12(0.96 to 1.30)0.145261.08(0.94 to 1.24)0.265191.11(0.98 to 1.27)0.11519
Atopy1.07(0.91 to 1.25)0.436811.14(0.97 to 1.35)0.125901.14(0.97 to 1.35)0.12590
Model 3Model 4
Ever wheeze1.1(1.03 to 1.17)0.0048171.09(1.03 to 1.15)0.004893
Ever asthma1.14(0.96 to 1.35)0.138231.06(0.89 to 1.28)0.52888
Current wheeze1.03(0.84 to 1.28)0.767411.09(0.89 to 1.33)0.40806
Current asthma1.17(0.94 to 1.45)0.168351.14(0.91 to 1.42)0.27915
Transient wheeze1.11(1.02 to 1.21)0.016861.11(1.02 to 1.20)0.01741
Persistent wheeze1.12(0.97 to 1.30)0.134781.10(0.96 to 1.27)0.17519
Atopy1.21(1.02 to 1.44)0.035461.15(0.97 to 1.36)0.12590
  • Relative risk represents change in outcome per 10 kg of maternal prepregnancy fat mass.

  • Model 1 Adjusted for potential confounders significantly associated with the outcome, excluding child's birth weight and gestation.

  • Ever wheeze-maternal education, asthma and rhinitis, child's gender and age last breast fed; Ever asthma-maternal education, asthma and smoking in pregnancy, and child's gender; Current wheeze-maternal education, asthma and atopy; Current asthma-maternal education and asthma; Transient wheeze-maternal height, parity, asthma and rhinitis, child's gender and age last breast fed; Persistent wheeze-maternal education, asthma and rhinitis and child's gender; Atopy-maternal social class, asthma and atopy, and child's gender.

  • Model 2 adjusted for potential confounders significantly associated with the outcome, including child's birth weight and gestation.

  • Ever wheeze-maternal education, asthma and rhinitis, child's gender, age last breast fed and gestation; Ever asthma-maternal education, asthma, smoking in pregnancy and parity, child's gender and gestation; Current wheeze-maternal education, asthma and atopy, child's gender and gestation; Current asthma-maternal education and asthma, and child's gestation; Transient wheeze-maternal height, parity, asthma and rhinitis, child's gender, age last breast fed and gestation; Persistent wheeze-maternal education, asthma and rhinitis, child's gender and gestation; Atopy-maternal social class, asthma and atopy, and child's gender.

  • Model 3 adjusted for increase in adiposity between birth and 6 months and potential confounders significantly associated with the outcome (listed in Model 2) including child's birth weight and gestation.

  • Model 4 adjusted for child's BMI at age 6 years and potential confounders significantly associated with the outcome including child's birth weight and gestation.

  • BMI, body mass index.