Table 5

Number (%) of patients with notable values for plasma potassium, blood glucose, pulse rate, blood pressure and QTc interval (Fridericia's)

Study 1Study 2
Indacaterol + tiotropiumTiotropium + placeboIndacaterol + tiotropiumTiotropium + placebo
Plasma potassium <3.5 mmol/litre13 (2.3)12 (2.1)9 (1.6)8 (1.4)
Blood glucose >9.99 mmol/litre11 (1.9)10 (1.8)14 (2.4)13 (2.3)
Pulse rate—high*2 (0.4)4 (0.7)01 (0.2)
Systolic blood pressure—high†13 (2.3)3 (0.5)6 (1.0)7 (1.2)
Diastolic blood pressure—high‡6 (1.1)4 (0.7)4 (0.7)2 (0.4)
QTc interval
 Absolute value >450/470 ms (men/women)18 (3.2)16 (2.9)10 (1.8)15 (2.6)
 Absolute value >500 ms0000
 Increase from baseline 30–60 ms23 (4.1)22 (3.9)24 (4.2)20 (3.5)
 Increase from baseline >60 ms01 (0.2)00

  • ↵* >130 bpm, or ≥120 bpm and ≥15 bpm increase from baseline.

  • ↵† >200 mm Hg, or ≥180 mm Hg and ≥20 mm Hg increase from baseline.

  • ↵‡ >115 mm Hg, or ≥105 mm Hg and ≥15 mm Hg increase from baseline.