Estimated mean and variance for the random effect of forced expiratory volume in 1 s (FEV1)% predicted on each domain of Cystic Fibrosis Quality of Life Questionnaire (CFQoL) together with estimated % of patients having a declining CFQoL domain with declining FEV1% predicted.
| Domain | FEV1% predicted Estimate (SE) | p Value* | % of patients (95% CI) |
|---|---|---|---|
| Physical functioning | |||
| Mean | 0.0217 (0.0039) | <0.001 | |
| Variance | 0.0014 (0.0003) | <0.001 | |
| 72 (64 to 81) | |||
| Social functioning | |||
| Mean | 0.0149 (0.0042) | <0.001 | |
| Variance | 0.0010 (0.0002) | <0.001 | |
| 68 (58 to 79) | |||
| Emotional responses | |||
| Mean | 0.0130 (0.0033) | <0.001 | |
| Variance | 0.0008 (0.0002) | <0.001 | |
| 68 (59 to 78) | |||
| Treatment issues | |||
| Mean | 0.0116 (0.0033) | <0.001 | |
| Variance | 0.0006 (0.0002) | 0.002 | |
| 68 (58 to 82) | |||
| Chest symptoms | |||
| Mean | 0.0205 (0.0032) | <0.001 | |
| Variance | 0.0005 (0.0001) | 0.003 | |
| 82 (73 to 91) | |||
| Body image | |||
| Mean | 0.0019 (0.0082) | 0.877 | |
| Variance | 0.0001 (0.0001) | 0.507 | |
| 58 (39 to 87) | |||
| Interpersonal relationships | |||
| Mean | 0.0116 (0.0032) | <0.001 | |
| Variance | 0.0010 (0.0002) | <0.001 | |
| 64 (57 to 73) | |||
| Career concerns | |||
| Mean | 0.0164 (0.0032) | <0.001 | |
| Variance | 0.0007 (0.0002) | <0.001 | |
| 73 (64 to 84) | |||
| Concerns for the future | |||
| Mean | 0.0077 (0.0027) | 0.044 | |
| Variance | 0.0005 (0.0001) | <0.001 | |
| 64 (54 to 73) | |||
*χ2 test with 1 df for the mean but with 3 df for the variance since the variance was tested jointly with the covariance with the other two random effects in the model.