Unadjusted and adjusted means and intervals (5th and 95th percentiles) for α1-antitrypsin (AAT) serum concentration in the six main SERPINA1 genotype classes
| SERPINA1 genotype | Unadjusted AAT serum concentrations, N=5981* | Adjusted AAT serum concentrations,† N=5768‡ | ||||||
| N | Mean, SD (g/litre) | 5th percentile | 95th percentile | N | Mean (g/litre) | 5th percentile | 95th percentile | |
| MM | 5366 | 1.298, 0.18 | 1.05 | 1.64 | 5175 | 1.298 | 1.079 | 1.572 |
| MS | 451 | 1.085, 0.16 | 0.88 | 1.37 | 438 | 1.082 | 0.902 | 1.312 |
| SS | 10 | 0.849, 0.10 | 0.73 | 1.06 | 10 | 0.823 | 0.735 | 1.009 |
| MZ | 143 | 0.805, 0.11 | 0.66 | 1.00 | 136 | 0.811 | 0.672 | 1.011 |
| SZ | 10 | 0.555, 0.06 | 0.49 | 0.66 | 9 | 0.554 | 0.480 | 0.638 |
| ZZ | 1 | 0.320, 0.00 | ||||||
↵* Subjects with rare variants (42) and samples with missing AAT levels (34) were excluded.
↵† Adjusted for age, sex, area, alcohol consumption (yes/no), systolic blood pressure, body mass index, smoking habit (never, former, current) and C-reactive protein levels.
↵‡ Additionally excluded were subjects with missing covariate data (212) and ZZ genotype due to insufficient frequency (1).