Table 3

Response to emphysematous lung sealant therapy at week 12

	Entire cohort,^* n=28	Complete fissure,^* n=13	Incomplete fissure,^* n=15	Difference in CF vs ICF p value^†
ΔFEV₁	19.1±21.5% (0.18±0.22 litres) p<0.001 vs baseline^‡ 55% responders^§	20.6±23.3% (0.19±0.26 litres) range −12 to +68%	17.7±20.5% (0.15±0.19 litres) range −3.0 to +68%	0.717
ΔFVC	11.2±17.1% (0.25±0.48 litres) p=0.003 vs baseline^‡ 41% responders^§	14.6±22.7% (0.29±0.50 litres) range −16.4 to +55.4%	9.3±17.4% (0.21±0.47 litres) range −24.5 to +27.4%	0.311
ΔRV/TLC	−6.5±10.7% p=0.007 vs baseline^‡	−9.1±10.0% range −22.9 to +4.4%	−4.1±11.1% range −25.4 to +16.8%	0.191
ΔRV	−9.3±15.8% (−0.51±0.81 litres) p<0.001 vs baseline^‡	−13.0±14.2% (−0.70±0.75 litres) range −33.1 to +10.4%	−5.5±17.0% (−0.31±0.86 litres) range −36.0 to +24.1%	0.215
ΔTLC	−2.6±8.8% (−0.73±1.90 litres) p<0.001 vs baseline^‡	−4.1±7.8% (−0.32±66 litres) range −14.7 to +11.1%	−1.1±9.7% (−0.10±0.79 litres) range −23.8 to +11.7%	0.422
ΔMRCD	−0.89±1.09 U p=0.004 vs baseline^‡ 55% responders^§	−1.23±1.30 U range −3.0 to 1.0	−0.67±0.76 U range −2.0 to 1.0	0.407
Δ6MWT	30.9±50.2 m p=0.005 vs baseline^‡ 31% responders^§	36.7±49.0 m range −59 to 127	27.3±52.5 m range −70 to 130	0.781
ΔSGRQ	−11.6±12.4 U p<0.001 vs baseline^‡ 71% responders^§	−13.6 U range −37.4 to 8.1	−9.8 U range −33.9 to 8.5	0.427

↵* Data normally distributed, presented as mean ± SD.
↵† Comparison of CFs and ICFs via Student t test; significance defined as p≤0.008 when corrected for multiple comparison.
↵‡ Comparison by paired t test.
↵§ Responder definitions: ΔFEV₁ and FVC ≥ +12%; ΔMRCD ≤−1 U; Δ6MWT ≥ 54 m; ΔSGRQ ≤−4 U.
6MWT, 6 min walk test; CF, complete fissure; FEV₁, forced expiratory volume in 1 s; FVC, forced vital capacity; ICF, incomplete fissure. MRCD, Medical Research Council Dyspnoea; RV, residual volume; SGRQ, St George's Respiratory Questionnaire; TLC, total lung capacity.