Top 10 downregulated mRNA in lung tissue from subjects with COPD compared with smokers without COPD
| Gene ID | Gene title | Gene symbol | Fold difference (COPD/normal smokers) | p Value | pFDR value | Function |
| 22870 | SAPS domain family, member 1 | SAPS1 | −4.46 | 3.15E-03 | 3.69E-03 | Protein phosphatase |
| 6435 | Surfactant, pulmonary-associated protein A1B | SFTPA1B | −4.23 | 2.90E-08 | 2.76E-07 | Binds surfactant phospholipids |
| 5507 | Protein phosphatase 1, regulatory (inhibitor) subunit 3C | PPP1R3C | −4.17 | 3.99E-05 | 1.01E-04 | Glycogen-targeting subunit, increases glycogen |
| 2662 | Growth differentiation factor 10 | GDF10 | −4.14 | 3.07E-05 | 8.04E-05 | TGFβ signalling |
| 5350 | Phospholamban | PLN | −3.93 | 1.78E-06 | 7.72E-06 | Calcium regulation |
| 25928 | Sclerostin domain containing 1 | SOSTDC1 | −3.87 | 2.68E-04 | 4.79E-04 | Inhibits TGFβ signaling and enhances Wnt signalling |
| 9353 | Slit homologue 2 (Drosophila) | SLIT2 | −3.48 | 4.32E-08 | 3.81E-07 | Cell migration and axonal navigation |
| 4094 | v-maf musculoaponeurotic fibrosarcoma oncogene homologue (avian) | MAF | −3.46 | 1.41E-06 | 6.35E-06 | Transcriptional activator or repressor, oncogene or tumor suppressor depending on context |
| 123624 | ATP/GTP binding protein-like 1 | AGBL1 | −3.37 | 7.95E-06 | 2.66E-05 | Tubulin processing |
| 4629 | Myosin, heavy chain 11, smooth muscle | MYH11 | −3.31 | 2.09E-06 | 8.78E-06 | Contractile protein |
COPD, chronic obstructive pulmonary disease; pFDR, positive false discovery rate; TGFβ, transforming growth factor β.