FDR significant* results from weighted GWAS
| SNP | Location (Chr: BP in hg18) | A1 | OR | Original p value† | Original rank | Weighted p value‡ | Gene (distance from gene) | Norway p value§ | NETT–NAS p value | Eclipse p value | Costa Rica RCHH | ||
| Cases (%) | Controls (%) | RCHH p value | |||||||||||
| rs1903003 | 4:90105320 | C | 0.75 | 7.18E–8 | 1 | 6.87E–8 | FAM13A(0) | 4.3E–4 | 1.4E–3 | 9.1E–3 | 1 (2%) | 0 (0%) | 0.2126 |
| rs7671167 | 4:90103002 | C | 0.76 | 8.59E–8 | 2 | 8.22E–8 | FAM13A(0) | 7.9E–4 | 2.7E–4 | 7.8E–3 | 1 (2%) | 0 (0%) | 0.2126 |
| rs1062980 | 15:76579582 | C | 0.76 | 4.81E–7 | 3 | 9.53E–8 | IREB2(0) | 9.9E–3 | 1.0E–2 | 3.6E–2 | 5 (9%) | 0 (0%) | 0.0164 |
| rs13180 | 15:76576543 | C | 0.76 | 5.01E–7 | 4 | 9.93E–8 | IREB2(0) | 7.9E–3 | 1.6E–2 | 4.3E–2 | 5 (9%) | 0 (0%) | 0.0164 |
| rs8034191 | 15:76593078 | C | 1.32 | 5.37E–7 | 5 | 1.06E–7 | IREB2(+12.22 kb) | 1.5E–4 | 8.7E–3 | 8.2E–1 | 5 (9%) | 0 (0%) | 0.0164 |
| rs12914385 | 15:76685778 | T | 1.29 | 1.42E–6 | 9 | 2.81E–7 | CHRNA3(0) | 1.4E–3 | 9.8E–3 | 9.5E–1 | 5 (9%) | 0 (0%) | 0.0164 |
| rs1051730 | 15:76681394 | A | 1.29 | 2.80E–6 | 14 | 5.54E–7 | CHRNA3(0) | 4.3E–4 | 2.1E–2 | 8.4E–1 | 5 (9%) | 0 (0%) | 0.0164 |
| rs17404727 | 15:47791375 | C | 1.28 | 4.71E–6 | 15 | 7.17E–7 | 1.9E–2 | 2.2E–2 | 3.4E–2 | 7 (12%) | 0 (0%) | 0.0049 | |
| rs996414 | 9:26570067 | G | 0.76 | 1.80E–6 | 11 | 8.76E–7 | 6.2E–4 | 8.8E–1 | 2.6E–1 | 2 (3%) | 0 (0%) | 0.1063 | |
| rs4480740 | 15:47543134 | A | 1.27 | 6.75E–6 | 17 | 1.03E–6 | FGF7(0) | 4.0E–2 | 2.5E–2 | 2.1E–2 | 7 (12%) | 0 (0%) | 0.0049 |
| rs12591300 | 15:47492033 | A | 1.27 | 8.78E–6 | 21 | 1.34E–6 | FGF7(–10.72 kb) | 3.9E–2 | 8.3E–2 | 2.5E–2 | 7 (12%) | 0 (0%) | 0.0049 |
| rs2656069 | 15:76532762 | C | 0.75 | 6.82E–6 | 18 | 1.35E–6 | IREB2(0) | 1.6E–1 | 2.6E–3 | 1.0E–2 | 5 (9%) | 0 (0%) | 0.0164 |
| rs2036534 | 15:76614003 | C | 0.75 | 6.98E–6 | 19 | 1.38E–6 | PSMA4(–5.798 kb) | 5.8E–2 | 7.4E–3 | 9.4E–2 | 5 (9%) | 0 (0%) | 0.0164 |
| rs2869967 | 4:90088355 | C | 1.29 | 1.48E–6 | 10 | 1.41E–6 | FAM13A1(0) | 4.7E–4 | 7.6E–3 | 4.4E–3 | 1 (2%) | 0 (0%) | 0.2126 |
* An FDR-corrected p value of 1.43E–6 was used as the cut-off for genome-wide significance.
† Results previously published by Cho et al.1
‡ The weighted p value is the original p value divided by the weight constructed from the RCHH (not shown).
§ p Values for individual cohorts are the original, unweighted p values.
COPD, chronic obstructive pulmonary disease; ECLIPSE, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints; FDR, false-discovery rate; FGF7, fibroblast growth factor-7; GWAS, genome-wide association study; NAS, Normative Aging Study; NETT, National Emphysema Treatment Trial; PSMA4, proteasome subunit, α-type, 4; RCHH, region of conserved homozygosity haplotype; SNP, single nucleotide polymorphism.