The adhesion molecules that have been identified as playing a role in neutrophil TEM
| Adhesion molecule | Protein family | Location | Ligand on neutrophil (n) or EC | References |
| Mac-1 (CD11b/CD18) | β2-integrin (CD11/CD18) | Neutrophil |
| 17 20 21 26 27 32 37 41 |
| LFA-1 (CD11a/CD18) | β2-integrin (CD11/CD18) | Neutrophil |
| 17 32 37 41 |
| CD157 | Glycosylphosphatidylinositol-linked molecule (member of the NADase/ADP-ribosylcyclase ectoenzyme family) | Neutrophil |
| 28 |
| CD177 | Glycosylphosphatidylinositol-linked molecule (member of the NADase/ADP-ribosylcyclase ectoenzyme family) | Neutrophil (45–65%) | PECAM-1 (EC) | 35 |
| CD99 | Not part of a defined protein family | Neutrophil | CD99 (EC) | 29 30 |
| PECAM-1 (CD31) | Immunoglobulin superfamily | Neutrophil | PECAM-1 (EC) | 26 29 39 |
| α9β1 (similar to VLA-4) | β1-integrin | Neutrophil | VCAM-1 (EC) | 38 |
| ICAM-1 | Immunoglobulin superfamily | Endothelial cell |
| 17 32 34 37 41 42 |
| ICAM-2 | Immunoglobulin superfamily | Endothelial cell | LFA-1 (n) | 26 37 |
| JAM-A | Immunoglobulin superfamily | Endothelial cell | LFA-1 (n) | 26 43 |
| JAM-C | Immunoglobulin superfamily | Endothelial cell | Mac-1 (n) | 26 27 |
| VCAM-1 | Immunoglobulin superfamily | Endothelial cell | α9β1 (n) | 38 |
| CD157 | Glycosylphosphatidylinositol-linked molecule (member of the NADase/ADP-ribosylcyclase ectoenzyme family) | Endothelial cell | ? (n) | 28 |
| CD99L2 | Related to CD99 | Endothelial cell | ? (n) | 30 |
| ESAM | Immunoglobulin superfamily | Endothelial cell | ? (n) | 31 |
These adhesion molecules and their ligands have been studied using a variety of inflammatory stimuli and experimental models. Different combinations of adhesion molecules have been shown to be involved under different conditions. JAM-A, JAM-C and PECAM-1 also bind homophilically in their role in EC–EC junctions.44
EC, endothelial cell; ESAM, endothelial cell selective adhesion molecule; ICAM, intercellular adhesion molecule; JAM, junctional adhesion molecule; LFA-1, lymphocyte function-associated antigen 1; Mac-1, macrophage antigen-1; PECAM, platelet endothelial cell adhesion molecule; TEM, transepithelial migration; VCAM, vascular cell adhesion molecule.