Table 2

Systemic upregulation of defensin and neutrophil protease gene expression in neutrophilic asthma

Gene symbol	Gene name	GenBank	p Value	Fold change
Gene symbol	Gene name	GenBank	p Value	NA vs EA	NA vs PGA	NA vs MGA
DEFA1	Defensin α1	NM_004084.2	0.006	4.6^*	3.4	2.9
DEFA1B	Defensin α1B (LOC728358)	NM_001042500.1	0.003	4.0^*	3.7^*	3.3
DEFA3	Defensin α3	NM_005217.2	0.003	4.7^*	3.8	2.9
DEFA4	Defensin α4	NM_001925.1	<0.001	2.6^*	2.4^*	2.2
CTSG	Cathepsin G	NM_001911.2	<0.001	2.1^*	2.2^*	1.8^*
ELA2	Elastase, neutrophil expressed	NM_001972.2	0.002	2.7^*	2.7^*	1.9

↵* Post-hoc Tukey HSD, p<0.01.
EA, eosinophilic asthma; ME/NA, mixed eosinophil and neutrophilic asthma; PGA, paucigranulocytic asthma.