Mean (SE) results from the pilot study for plasma Aα-Val360, myeloperoxidase (MPO) and calprotectin (CP) for subjects with normal alpha-1-antitrypsin (A1AT) and those with A1AT deficiency of the PiZ phenotype
| Aα-Val360 (nM) | MPO (nM) | CP (nM) | |||||||
| Basal | Stimulated | p (basal vs stimulated) | Basal | Stimulated | p (basal vs stimulated) | Basal | Stimulated | p (basal vs stimulated) | |
| Normal (n=12) | 3.64 (0.38) | 76.51 (6.03) | 1.02×10−7 | 15.57 (2.41) | 321.05 (34.95) | 2.67×10−6 | 69.92 (13.94) | 261.63 (29.42) | 3.32×10−4 |
| PiZ (n=15) | 9.46 (1.06) | 157.43 (20.60) | 1.98×10−5 | 20.16 (2.77) | 291.40 (17.32) | 1.19×10−7 | 70.04 (18.28) | 287.05 (80.33) | 0.016 |
All values increased significantly following stimulation with the ionophore A23187. The Aα-Val360 values were higher in the A1AT-deficient samples both before and after stimulation compared with those from normal subjects.