Factors associated with 30-day PE-related mortality in 591 normotensive patients with acute symptomatic PE
| Risk factor | Unadjusted OR (95% CI) | p Value | Adjusted OR (95% CI) | p Value |
| Age >65 years | 2.33 (0.89 to 6.10) | 0.08 | – | – |
| Male gender | 0.70 (0.35 to 1.41) | 0.32 | – | – |
| COPD | 1.31 (0.44 to 3.85) | 0.63 | – | – |
| CHF | 0.93 (0.27 to 3.14) | 0.91 | – | – |
| Cardiac troponin I >0.1 ng/ml | 2.66 (1.36. to 5.20) | 0.004 | 2.66 (1.36 to 5.20)‡ | 0.004 |
| RVD (echocardiogram) | 2.57 (1.28 to 5.16) | 0.008 | 2.57 (1.28 to 5.16)‡ | 0.008 |
| Presence of DVT (CCUS) | 2.48 (1.26 to 4.88) | 0.009 | 2.20 (1.10 to 4.38)§ | 0.02 |
| Pulse ≥110 beats/min | 1.92 (0.95 to 3.88) | 0.07 | – | – |
| Arterial oxyhaemoglobin saturation <90% | 1.99 (1.02 to 3.88) | 0.04 | – | – |
| Systolic blood pressure <120 mm Hg | 1.64 (0.83 to 3.21) | 0.15 | – | – |
| Dyspnoea | 1.05 (0.48 to 2.28) | 0.90 | – | – |
| Chest pain | 0.75 (0.38 to 1.47) | 0.40 | – | – |
| Syncope | 0.85 (0.34 to 2.08) | 0.72 | – | – |
| Cancer* | 3.12 (1.53 to 6.37) | 0.002 | – | – |
| Immobilisation† | 2.21 (1.16 to 4.21) | 0.02 | – | – |
| Recent surgery | 0.54 (0.13 to 2.32) | 0.41 | – | – |
| History of VTE | 1.03 (0.35 to 3.01) | 0.95 | – | – |
| Thrombolysis | 0.99 (0.13 to 7.73) | 0.99 | – | – |
↵* Active or under treatment in the past year.
↵† Immobilised patients are defined in this analysis as non-surgical patients who had been immobilised (ie, total bed rest with bathroom privileges) for 4 days or more in the month before pulmonary embolism (PE) diagnosis.
↵‡ No variables showed evidence of confounding.
↵§ Adjusted by cancer.
CCUS, lower extremity complete compression ultrasound; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; DVT, deep vein thrombosis; RVD, right ventricular dysfunction; VTE, venous thromboembolism.