Table 4

Summary of baseline (gene array) and year one (PCR) results

Gene ID	Gene array Fold Change	p value	PCR Fold Change	p value
ADPN/PNPLA3	−3.02	<0.0001	−1.64	0.0077
ANKRD33	2.29	<0.0001	1.63	0.0264
DAAM2	2.45	<0.0001	3.24	<0.0001
EDN1	2.10	<0.0001	1.19	0.3433
EPHX1	−2.60	<0.0001	−1.69	0.0034
FABP4	−3.18	<0.0001	−2.86	<0.0001
IL18R1	2.28	<0.0001	1.95	0.0055
IL1RL1	2.35	<0.0001	1.89	0.0013
PRSS21	−3.01	<0.0001	−1.91	0.0116
SCD	−2.90	<0.0001	−1.57	0.0105
TPST	2.96	<0.0001	1.92	0.0003
ZNF165	2.41	<0.0001	1.37	0.0226

Severe COPD (GOLD 3/4) vs moderate COPD (GOLD 2) subjects for the nominated gene set. Positive fold change values indicate increase in GOLD stage 3/4 compared to GOLD stage 2.