Table 3

Genes showing significantly different expression according to the degree of emphysema

Gene name	Gene ID	P Value	Fold change	Function
UNKNOWN	1568375_at	0.0004	2.83	Defence response
TPST1	204140_at	<0.0001	2.78	Peptidyl-tyrosine sulfation /// inflammatory response
ANKRD33	242209_at	<0.0001	2.73	Transcription Factor
ZBTB16	228854_at	0.009	2.68	Transcription Factor
DAAM2	212793_at	0.0002	2.58	Cellular component organisation and biogenesis
TKTL1	214183_s_at	<0.0001	2.57	Glucose catabolic process /// metabolic process
IL18R1	206618_at	<0.0001	2.47	Signal transduction /// innate immune response
TANK	237609_at	0.0007	2.43	Signal Transduction with TRAF
KIAA1727	226599_at	<0.001	2.42	Cellular component organisation and biogenesis
EGR3	1562247_at	<0.001	2.41	Transcription regulator
ENPP3	232737_s_at	<0.0001	−2.50	Phosphate metabolic process
CPE	201116_s_at	0.003	−2.55	Protein modification process /// proteolysis
C5orf4	220751_s_at	0.0006	−2.59	Metabolic process
FABP4	235978_at	0.003	−2.60	Cytokine production /// negative regulation of protein kinase activity
SPRR2G	236119_s_at	0.002	−2.61	Epidermis development /// keratinocyte differentiation
SYTL4	229991_s_at	<0.0001	−2.62	Transport /// intracellular protein transport /// exocytosis
CADPS2	219572_at	0.0004	−2.63	Transport /// exocytosis /// protein transport
ADPN	233030_at	0.0003	−2.85	Metabolic process /// lipid catabolic process
BACE1	222463_s_at	0.0009	−2.93	Proteolysis /// proteolysis
TPD52L1	203786_s_at	<0.0001	−3.07	G2/M transition of mitotic cell cycle /// DNA fragmentation during apoptosis

The 10 most highly up and down regulated genes are shown. Function was obtained by mapping to GO Processes or manual literature mapping. Positive fold change values indicate increase in LAAH (more emphysema) compared to LAAL (less emphysema).