Baseline characteristics of subjects
| Asthma | Control | |||||||
| Never smokers | Ex-smokers | Current smokers | p Value | Never smokers | Ex-smokers | Current smokers | p Value | |
| n=26 | n=27 | n=27 | n=24 | n=15 | n=7 | |||
| Maternal age (years) | 28.7±4.2 | 27.6±4.5 | 26.4±5.9 | NS | 30.0±3.7* | 26.8±6.0 | 23.3±5.3 | 0.005 |
| Gravidity | 2.5 (1–4) | 3 (1–3) | 3 (2–4) | NS | 1.5 (1–3) | 2 (1–2) | 2 (1–5) | NS |
| Parity | 1 (0–2) | 0 (0–1) | 1 (0–2) | NS | 0 (0–1) | 0 (0–1) | 0 (0–3) | NS |
| Weight (kg) | 75.3±14.7 | 80.1±21.2* | 67.3±12.1 | 0.046 | 81.8±17.8 | 73.9±18.4 | 82.1±19.8 | NS |
| BMI (antenatal) | 27.8±5.3 | 29.2±6.7 | 25.2±4.8* | NS | 28.9±5.0 | 28.1±6.4 | 32.0±7.3 | NS |
| % Single | 1 (4%)* | 4 (15%) | 12 (46%) | 0.001 | 1 (4%)* | 1 (8%) | 4 (57%) | 0.007 |
| % predicted FEV1 | 96.0±14.0 | 92.4±14.6 | 92.3±15.1 | NS | 99.7±13.2 | 94.9±13.3 | 102±8.4 | NS |
| % predicted FVC | 101.2±11.7 | 99.8±12.3 | 99.1±15.5 | NS | 106±13.4 | 92.9±27.0 | 108.9±10.5 | NS |
| Lowest FENO (ppb) | 13 (10.1–19.6) | 17.9 (9–30.8)* | 8.3 (6.6–16.9) | 0.018 | 10.2 (7.0–13.7) | 10.1 (8.1–14.9) | 7.8 (7.0–10.0) | NS |
| ECO at visit 1 | 1 (1–1)* | 1 (1–2)* | 9.5 (4.5–17.5) | 0.0001 | 1 (1–1)* | 1 (1–2)* | 15 (7–22) | 0.0001 |
Values are mean ± SD, median (IQR) or n (%) of subjects in each group.
↵* Post hoc test significant p<0.017 vs current smokers.
BMI, body mass index; ECO, exhaled carbon monoxide; FENO, fractional exhaled nitric oxide; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; NS, not significant.