Predictors of sputum culture non-conversion for 546 patients with pulmonary tuberculosis who were sputum culture positive at baseline and followed up at the end of the second month of intensive phase treatment
| All (N=546) | Converted (N=516) | Not converted (N=30) | p Value | Crude OR (95% CI) for non-conversion | p Value | Adjusted* OR (95% CI) for non-conversion | p Value | |
| Age (years) (N=546) | ||||||||
| 15–24 | 103 | 95 (92.2%) | 8 (7.8%) | 0.31 | 2.13 (0.77 to 5.84) | 0.14 | 2.09 (0.76 to 5.77) | 0.15 |
| 25–34 | 210 | 202 (96.2%) | 8 (3.8%) | 1.0 | 1.0 | |||
| 35–44 | 234 | 124 (92.5%) | 10 (7.5%) | 2.04 (0.78 to 5.30) | 0.15 | 1.83 (0.70 to 4.80) | 0.22 | |
| ≥45 | 99 | 95 (96.0%) | 4 (4.0%) | 1.06 (0.31 to 3.62) | 0.92 | 2.00 (0.83 to 4.82) | 0.87 | |
| Sex (N=546) | ||||||||
| Female | 201 | 194 (96.5%) | 7 (3.5%) | 0.12 | 1.0 | 1.0 | ||
| Male | 345 | 322 (93.3%) | 23 (6.7%) | 1.98 (0.83 to 4.70) | 0.12 | 2.00 (0.83 to 4.82) | 0.12 | |
| Smoking (N=543) | ||||||||
| Never | 351 | 336 (95.7%) | 15 (4.3%) | 0.20 | 1.0 | 1.0 | ||
| Past | 55 | 50 (90.9%) | 5 (9.1%) | 2.24 (0.78 to 6.43) | 0.13 | 2.18 (0.69 to 6.82) | 0.18 | |
| Current | 137 | 127 (92.7%) | 10 (7.3%) | 1.76 (0.77 to 4.03) | 0.18 | 1.69 (0.66 to 4.32) | 0.27 | |
| Culture grading (N=546)† | ||||||||
| ≤2+ | 157 | 155 (98.7%) | 2 (1.3%) | 0.006 | 1.0 | 1.0 | ||
| 3+ | 389 | 361 (92.8%) | 28 (7.2%) | 6.01 (1.41 to 25.54) | 0.02 | 5.70 (1.34 to 24.31) | 0.02 | |
| BCG scar (N=539) | ||||||||
| Present | 444 | 426 (96.0%) | 18 (4.1%) | 0.003 | 1.0 | 1.0 | ||
| Not present | 95 | 84 (88.4%) | 11 (11.6%) | 3.10 (1.41 to 6.80) | 0.005 | 3.35 (1.48 to 7.58) | 0.004 | |
| CD4 (cells/μl) (N=546) | ||||||||
| <200 | 122 | 117 (95.9%) | 5 (4.1%) | 1.0 | 1.0 | |||
| 201–350 | 136 | 126 (92.7%) | 10 (7.4%) | 0.50 | 1.86 (0.62 to 5.59) | 0.27 | 1.86 (0.61 to 5.68) | 0.28 |
| >351 | 288 | 273 (94.8%) | 15 (5.2%) | 1.29 (0.46 to 3.62) | 0.63 | 1.16 (0.40 to 3.36) | 0.79 | |
| HIV status (N=546) | ||||||||
| Negative | 330 | 310 (93.9%) | 20 (6.1%) | 0.47 | 1.0 | 1.0 | ||
| Positive | 216 | 206 (95.4%) | 10 (4.6%) | 0.75 (0.35 to 1.64) | 0.47 | 0.87 (0.39 to 1.96) | 0.74 | |
| Anaemia (N=546)‡ | ||||||||
| Not present | 117 | 109 (93.2%) | 8 (6.8%) | 0.47 | 1.0 | 1.0 | 0.61 | |
| Present | 429 | 407 (94.9%) | 22 (5.1%) | 0.74 (0.32 to 1.70) | 0.47 | 0.80 (0.34 to 1.87) | ||
| BMI (kg/m2) (N=546) | ||||||||
| ≥18.5 | 227 | 218 (96.0%) | 9 (4.0%) | 0.24 | 1.0 | 1.0 | ||
| 17.0–18.5 | 135 | 124 (91.9%) | 11 (8.2%) | 1.39 (0.55 to 3.50) | 0.48 | 1.32 (0.52 to 3.37) | 0.56 | |
| <17.0 | 184 | 174 (94.6%) | 10 (5.4%) | 2.15 (0.87 to 5.33) | 0.10 | 1.86 (0.73 to 4.70) | 0.19 | |