Copenhagen City Heart Study | Copenhagen General Population Study | |||||
No event | COPD spirometrically defined | COPD hospitalisation | No event | COPD spirometrically defined | COPD hospitalisation | |
Women/men | 4221/3344 | 845/735 | 590/495 | 16890/14640 | 1517/1575 | 658/577 |
Age, years | 42 (32–52) | 49 (42–56) | 50 (44–55) | 57 (47–66) | 67 (57–74) | 68 (60–75) |
Never smokers, % | 28 | 12 | 5 | 54 | 29 | 19 |
Ex-smokers, % | 18 | 12 | 9 | 29 | 32 | 41 |
Current smokers, % | 54 | 76 | 86 | 17 | 39 | 40 |
Pack years | 5.0 (0–18) | 18 (8.8–30) | 23 (14–34) | 2.0 (0–18) | 19 (2.6–40) | 28 (5.7–45) |
Body mass index, kg/m2 | 24 (22–26) | 24 (22–27) | 24 (22–27) | 26 (23–29) | 25 (23–28) | 26 (23–29) |
Plasma CRP | 1.6 (1.1–2.7) | 1.9 (1.3–3.7) | 2.4 (1.5–5.0) | 1.5 (1.0–2.6) | 2.0 (1.2–4.4) | 2.5 (1.3–5.4) |
Minimum–maximum | 0.1–103 | 0.1–164 | 0.1–103 | 0.1–330 | 0.1–122 | 0.1–71 |
FEV1, % predicted | 94 (85–104) | 78 (68–89) | 80 (67–93) | 92 (83–101) | 65 (55–73) | 62 (48–79) |
FVC, % predicted | 93 (84–104) | 88 (77–97) | 85 (75–97) | 93 (84–102) | 80 (70–89) | 75 (62–88) |
FEV1/FVC | 0.83 (0.78–0.87) | 0.74 (0.67–0.81) | 0.76 (0.70–0.83) | 0.79 (0.75–0.83) | 0.64 (0.58–0.67) | 0.66 (0.56–0.74) |
Values are median (IQR) or percentage. Values for the Copenhagen City Heart Study are pre-outcome values taken prior to the development of COPD. COPD spirometrically defined=FEV1/FVC<0.7 and FEV1<80% of predicted, excluding asthmatics. COPD hospitalisation=ICD8:491–492; ICD10:J41–J44. We used the Copenhagen City Heart Study to test question 1 (CRP level is associated with COPD risk) and question 3 (CRP genotype is associated with COPD risk), and the Copenhagen General Population Study to test question 2 (CRP genotype is associated with CRP level) and retest question 3.