Distribution of 11478G→A genotype frequencies in healthy participants and those with COPD from the ELSA and Whitehall II cohorts
| ELSA COPD (n=199) | ELSA controls (n=1606) | χ2 p value | |
| GG (wild type) | 173 (87%) | 1383 (86%) | |
| GA | 26 (13%) | 214 (13%) | |
| AA | 0 (0%) | 9 (1%) | |
| HWE p value | 0.8170 |
| Whitehall COPD (n=153) | Whitehall controls (n=2580) | χ2 p value | |
| GG (wild type) | 124 (81%) | 2250 (87%) | 0.22 |
| GA | 27 (18%) | 321 (12%) | |
| AA | 2 (1%) | 9 (0%) | |
| HWE p value | 0.7028 | 0.4933 |
Data are limited to those with complete lung function data at two time points.
ELSA, English Longitudinal Study of Ageing; HWE, Hardy–Weinberg equilibrium.