Table 1

MIRU-VNTR profiles of clusters identified by MIRU-VNTR fingerprinting with 15 loci and their prevalence in the UK Mycobacterium tuberculosis Strain Typing Database (STD)

Cluster	MIRU-VNTR profile	ETR			Number of isolates	Comments	Prevalence in STD
Cluster	MIRU-VNTR profile	A	B	C	Number of isolates	Comments	Prevalence in STD
1^*	222325153323	4	1	4	2		Unique profile not otherwise in STD
2^*	223125153322	3	2	4	9		118 matching isolates
3	223315153324	3	2	4	2	Both South Asian	6 matching isolates
4	223325153324	5	2	4	2	Both South Asian	312 matching isolates (12 loci)
5	223425173533	NA	2	4	2	Both South Asian	24 matching isolates (12 loci)
6	224125163324	3	2	3	2	Both South Asian	45 matching isolates
7	224325143323	2	2	3	7	All white, linked to a pub	1 matching isolate
8	224325143325	4	2	3	3	All white, linked to a pub	11 matching isolates
9^*	224325153323	3	2	4	5		161 matching isolates
10	224325163325	3	2	3	3	All white, linked to a pub	2 matching isolates
11	224325163325	4	2	3	4	All white, linked to a pub	Unique profile not in STD
12	224326163326	2	2	4	2	Both South Asian	1 matching isolate
13	224425173323	4	2	2	3	All South Asian	9 matching isolates
14	224425173533	5	2	2	5		Unique profile not otherwise in STD
15^*	225125113322	3	2	4	2		174 matching isolates
16^*	225225173533	3	2	2	2		12 matching isolates (12 loci)
17^*	225313153323	3	2	3	2		151 matching isolates
18	225325133323	4	2	2	2	South Asian family, linked	38 matching isolates
19	225421163533	5	2	2	2	Both South Asian	Unique profile not otherwise in STD
20	225425143533	4	2	2	2	Both South Asian	26 matching isolates
21	225425173531	4	2	2	4	All South Asian	24 matching isolates
22	225425173533	3	2	2	3	All South Asian	19 matching isolates
23	225425173533	4	2	2	13	All South Asian	426 matching isolates
24	225425173533	5	2	2	5	All South Asian	1 matching isolate
25^*	225425173533	Null	2	2	2		^†103 matching isolates (14 loci)
26	225425183533	4	2	2	2	Both South Asian	41 matching isolates
27	226225173533	4	2	2	2	Both South Asian	3 matching isolates
28	226425152523	5	2	2	2	South Asian, family linked	Unique profile not otherwise in STD
29	226425163523	4	2	2	2	Both South Asian	3 matching isolates
30	226425173332	3	2	2	2	Both South Asian	1 matching isolate
31	226425173423	4	2	2	3	All South Asian	186 matching isolates
32	226425173423	5	2	2	3	All South Asian	3 matching isolates
33	226425173423	4	2	2	2	Both South Asian	186 matching isolates
34	226425173424	4	2	2	2	Both South Asian	32 matching isolates
35	226425173531	4	2	2	2	Both South Asian	26 matching isolates
36	226425173532	4	2	2	2	Both South Asian	38 matching isolates
37	226425173532	5	2	2	2	Both South Asian	Unique profile not otherwise in STD
38	226425173533	4	2	2	5	All South Asian	183 matching isolates
39	226425173533	5	2	2	5	All South Asian	1 matching isolate
40^*	226425183531	4	2	2	2		7 matching isolates
41	227425173522	4	2	2	2	Both South Asian	Unique profile not otherwise in STD
42	227425173532	4	2	2	5	All South Asian	Unique profile not otherwise in STD
43	244326221533	10	4	4	2	Both South Asian	2 matching isolates
44	244327223426	6	1	4	2	Both South Asian	Unique profile not otherwise in STD
45	254326223513	7	NA	2	2	Both South Asian	Unique profile not otherwise in STD
46	254326223633	6	1	4	2	Both South Asian	Unique profile not otherwise in STD
47^*	274326223633	6	1	4	2		2 matching isolates
48	274328223534	7	1	4	2	Both South Asian	Unique profile not otherwise in STD

↵* Interracial clusters.
↵† Cluster 25 profile. 103 isolates in STD with the ETR A locus as a ‘null’ negative allele result. Appears to be a peculiarity of this strain. Clusters 4, 5, 16, 29, 34, and 43 are included because they were indistinguishable at 12 MIRU-VNTR loci. At the time of analysis (March 2010) there were 24 869 records on the STD, from Newcastle RCM (3981), Birmingham RCM (7341), London MRU (7769), Scottish SRML (1598), Welsh Reference Lab (1526), and the London Study 1995–7 (2654).
ETR, exact tandem repeat; MIRU, mycobacterial interspersed repetitive unit; NA, no amplification; STD, Strain Typing Database; VNTR, variable number tandem repeat.