Table 2

Analysis of time to 5% decline of baseline FEV1 % predicted

Unadjusted HRAdjusted HR*
<1 exacerbation/year1.291.33
versus95% CI 0.95 to 1.7795% CI 0.96 to 1.84
1–2 exacerbations/yearp=0.11p=0.08
<1 exacerbation/year1.471.55
versus95% CI 1.07 to 2.0195% CI 1.10 to 2.18
>2 exacerbations/yearp=0.02p=0.01
  • * Adjusted for age, sex, body mass index, infection with Burkholderia cepacia, transmissible Pseudomonas aeruginosa, baseline forced expiratory volume in 1 s (FEV1), cystic fibrosis co-morbidities and maintenance therapies.