Prediction rule test characteristics for 30-day PE-related mortality in 591 normotensive patients with acute symptomatic PE
| Troponin parameter (95% CI) | TTE parameter (95% CI) | CCUS parameter (95% CI) | Troponin plus TTE parameter (95% CI) | Troponin plus CCUS parameter (95% CI) | TTE plus CCUS parameter (95% CI) | Troponin plus TTE plus CCUS parameter (95% CI) | |
| Positive test N, % | 190 (32.1%) | 120 (20.3%) | 228 (38.5%) | 59 (10.0%) | 82 (13.9%) | 51 (8.6%) | 24 (4.1%) |
| Sensitivity, % | 54.0 (38.0 to 70.1) | 37.8 (22.2 to 53.5) | 59.5 (43.6 to 75.3) | 24.3 (10.5 to 38.1) | 37.8 (22.2 to 53.5) | 27.0 (12.7 to 41.3) | 13.5 (2.5 to 24.5) |
| Specificity, % | 69.3 (65.5 to 73.1) | 80.9 (77.6 to 84.1) | 62.8 (58.8 to 66.8) | 91.0 (88.6 to 93.4) | 87.7 (85.0 to 90.5) | 92.6 (90.4 to 94.8) | 96.6 (95.0 to 98.1) |
| Positive predictive value, % | 10.5 (6.2 to 14.9) | 11.7 (5.9 to 17.4) | 9.6 (5.8 to 13.5) | 15.2 (6.1 to 24.4) | 17.1 (8.9 to 25.2) | 19.6 (8.7 to 30.5) | 20.8 (4.6 to 37.1) |
| Negative predictive value, % | 95.8 (93.8 to 97.7) | 95.1 (93.2 to 97.1) | 95.9 (93.8 to 97.9) | 94.7 (92.8 to 96.6) | 95.5 (93.7 to 97.3) | 95.0 (93.2 to 96.8) | 94.4 (92.5 to 96.3) |
| Positive likelihood ratio | 1.76 (1.28 to 2.43) | 1.98 (1.26 to 3.09) | 1.60 (1.20 to 2.13) | 2.70 (1.44 to 5.04) | 3.08 (1.93 to 4.93) | 3.65 (1.99 to 6.69) | 3.94 (1.56 to 9.96) |
| Negative likelihood ratio | 0.66 (0.47 to 0.94) | 0.77 (0.60 to 0.99) | 0.65 (0.43 to 0.96) | 0.83 (0.69 to 1.0) | 0.71 (0.55 to 0.91) | 0.79 (0.65 to 0.96) | 0.90 (0.79 to 1.02) |
CCUS, lower extremity complete compression ultrasound; PE, pulmonary embolism; TTE transthoracic echocardiography.