Cox proportional hazard models to define the association of handgrip weakness with mortality using 10th centile (A) and 5th centile (B) of the healthy population as ref. 3
| HR (95% CI) | p Value | |
|---|---|---|
| (A) | ||
| Unadjusted | ||
| Handgrip weakness (reference: >C10) | 1.80 (1.25 to 2.54) | 0.002 |
| Adjusted for ADO index and BMI | ||
| Handgrip weakness (reference: >C10) | 1.53 (1.07 to 2.12) | 0.02 |
| ADO index (continuous) | 1.50 (1.36 to 1.66) | <0.0001 |
| BMI (continuous) | 0.92 (0.89 to 0.95) | <0.0001 |
| (B) | ||
| Unadjusted | ||
| Handgrip weakness (reference: >C5) | 1.71 (1.08 to 2.58) | 0.024 |
| Adjusted for ADO index and BMI | ||
| Handgrip weakness (reference: >C5) | 1.50 (0.96 to 2.27) | 0.08 |
| ADO index (continuous) | 1.51 (1.37 to 1.67) | <0.0001 |
| BMI (continuous) | 0.92 (0.89 to 0.96) | <0.0001 |
ADO index, multidimensional disease index based on age, dyspnoea symptoms and FEV1 (range 0–10); BMI, body mass index; C10, centile 10; C5, 5th centile.