Characteristics and biomarker assessment of CTEPH and control subjects
| CTEPH Pre PEA | CTEPH Post PEA | Healthy controls | ||||
| Median | 95% CI | Median | 95% CI | Median | 95% CI | |
| Age | 63.59 | 58.6–66.2 | 64.09 | 60.98–66.59 | 60.64 | 58.00–61.46 |
| IL6 (pg/ml) | 0.13 | 0.13–0.13 | 0.13 | 0.13–0.13 | 0.13 | 0.13–0.13 |
| IL8 (pg/ml)£ | 7.22 | 4.76–9.34 | 4.12 | 1.84–5.68 | 0.13 | 0.13–1.94 |
| IL10 (pg/ml)£$ | 1.85 | 1.29–2.96 | 1.44 | 0.91–2.18 | 0.13 | 0.13–0.20 |
| TNFα (pg/ml)£$ | 9.69 | 7.89–11.10 | 9.21 | 6.46–10.91 | 4.72 | 0.45–6.03 |
| hs CRP (pg/ml)£ | 2.86 | 2.23–3.91 | 0.72 | 0.62–2.01 | ||
| VEGFa (pg/ml) | 157.68 | 121.21–244.79 | 142.37 | 53.71–178.69 | 36.78 | 13.70–167.42 |
| VEGFc (pg/ml)£$ | 21.96 | 8.71–35.73 | 17.10 | 9.33–25.14 | 54.22 | 49.25–62.74 |
| VEGFd (pg/ml) | 30.51 | 6.90–50.36 | 27.72 | 8.93–38.97 | 86.18 | 36.16–108.62 |
| Ang2 (pg/ml)*£ | 1266.79 | 1079.31–1649.42 | 757.07 | 545.04–922.97 | 575.99 | 539.78–642.32 |
| BMP9 (pg/ml) | 25.47 | 18.13–28.79 | 24.87 | 18.49–33.77 | 29.56 | 16.63–40.97 |
| Endoglin (pg/ml)* | 242.30 | 209.53–285.24 | 117.22 | 34.50–160.43 | 61.71 | 27.40–247.32 |
| ProBNP (pg/ml) | 575.00 | 130.1–1142 | 234.00 | 195.50–270.00 | ||
| RAP (mmHg) | 8.00 | 7.00–9.00 | 7.00 | 6.00–8.00 | ||
| mPAP (mmHg)* | 44.50 | 39.50–47.00 | 26.00 | 24.00–27.00 | ||
| CI (L/min/m2)* | 2.29 | 2.19–2.40 | 2.51 | 2.44–2.66 | ||
| PVR (Wood units)* | 6.40 | 5.52–8.52 | 2.80 | 2.60–3.06 | ||
| 6mwt distance (m)* | 267 | 242–316 | 353 | 328–380 | ||
| WHO class* | 3 | 3–3 | 2 | 2–2 | ||
↵*Variables different between Pre and Post PEA samples.
↵£Variables different between Pre PEA and healthy control samples.
↵$Variables different between Post PEA and healthy control samples.
IL – interleukin, TNFα – tumour necrosis factor α, hsCRP – high sensitivity C-reactive protein, VEGF – vascular endothelial growth factor, Ang2 – angiopoietin 2, BMP9 – bone morphogenetic protein 9, ProBNP – prohormone brain natriuretic peptide, RAP – right atrial pressure, mPAP –mean pulmonary artery pressure, CI – cardiac index, PVR – pulmonary vascular resistance, 6mwt – six minute walk test.