Pulmonary function test by year | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | p for trend* | |
%VC (%) | ||||||||||
All | 98.3±11.4 | 100.2±11.7 | 98.4±12.1 | 101.0±11.9 | 100.9±11.5 | 102.6±11.5 | 105.0±11.5 | 106.9±12.3 | 102.5±11.6 | <0.001 |
Gr 1 | 102.1±9.7 | 104.2±9.1 | 102.7±10.1 | 105.1±10.5 | 104.6±10.0 | 105.8±9.7 | 107.2±9.5 | 109.1±11.2 | 104.8±8.7 | 0.0327 |
Gr 2 | 99.7±12.1 | 101.6±11.8 | 99.9±11.6 | 103.2±11.9 | 102.9±11.5 | 104.6±11.1 | 107.0±13.0 | 108.9±13.0 | 103.6±12.7 | 0.0103 |
Gr 3 | 98.6±11.7 | 101.1±12.3 | 99.8±13.0 | 101.3±12.6 | 101.2±11.4 | 103.7±12.6 | 106.4±11.6 | 107.1±12.4 | 104.6±11.8 | 0.0053 |
Gr 4 | 92.6±10.7 | 93.7±11.1 | 91.2±11.0 | 94.6±10.5 | 95.1±11.3 | 96.5±10.9 | 99.5±10.6 | 102.5±12.1 | 96.9±11.5 | 0.0010 |
%FEV1 (%) | ||||||||||
All | 92.7±10.4 | 93.3±12.0 | 92.1±12.7 | 92.0±12.4 | 91.3±12.5 | 92.9±11.4 | 94.9±12.0 | 94.6±16.3 | 92.8±12.9 | 0.3132 |
Gr 1 | 96.1±5.9 | 96.2±6.7 | 96.5±8.2 | 95.5±9.3 | 95.3±5.9 | 96.9±8.0 | 97.7±9.5 | 95.7±23.4 | 96.9±11.0 | 0.7717 |
Gr 2 | 94.0±9.9 | 95.7±11.2 | 93.4±10.4 | 93.9±10.8 | 91.9±9.8 | 93.7±10.1 | 96.4±11.5 | 96.3±12.0 | 92.4±11.2 | 0.9350 |
Gr 3 | 95.1±10.6 | 96.0±11.9 | 95.3±12.2 | 94.9±11.5 | 94.2±12.3 | 96.5±10.7 | 98.5±10.7 | 98.8±12.2 | 96.3±12.3 | 0.2819 |
Gr 4 | 85.6±11.5 | 85.5±14.1 | 83.1±14.9 | 83.9±14.4 | 83.6±15.1 | 84.5±12.5 | 87.1±13.2 | 87.6±13.5 | 85.6±14.4 | 0.5114 |
FEV1/FVC ratio (%) | ||||||||||
All | 82.8±7.0 | 81.5±7.1 | 81.2±7.6 | 80.1±8.6 | 79.9±9.0 | 79.8±7.9 | 78.8±8.1 | 78.8±8.3 | 78.6±8.2 | <0.001 |
Gr 1 | 82.4±5.8 | 80.9±5.8 | 81.1±6.2 | 79.6±6.7 | 79.2±6.1 | 79.6±6.1 | 78.7±6.3 | 79.4±6.6 | 79.8±6.7 | 0.0646 |
Gr 2 | 82.4±6.1 | 81.6±6.1 | 81.3±6.7 | 79.8±7.3 | 79.8±6.2 | 80.4±8.6 | 78.7±7.1 | 78.7±6.9 | 77.5±6.6 | 0.0041 |
Gr 3 | 84.9±7.1 | 83.8±6.4 | 83.3±6.7 | 82.5±7.9 | 82.4±7.8 | 81.9±7.8 | 81.6±7.9 | 81.9±7.5 | 80.6±7.9 | 0.0279 |
Gr 4 | 81.3±8.9 | 79.7±9.3 | 79.2±10.0 | 78.4±11.7 | 78.3±13.4 | 77.1±9.3 | 76.1±10.3 | 75.3±10.7 | 76.5±10.6 | 0.0239 |
%DLCO (%) | ||||||||||
All | 115.4±16.5 | 110.1±18.2 | 105.2±17.7 | 104.1±17.0 | 109.1±18.0 | 113.0±19.1 | 119.3±19.8 | 112.3±18.6 | 114.0±19.9 | 0.0159 |
Gr 1 | 124.4±14.0 | 117.6±15.0 | 115.6±12.7 | 113.0±12.8 | 119.6±18.3 | 121.6±15.6 | 128.0±17.5 | 121.0±14.2 | 125.9±13.9 | 0.6671 |
Gr 2 | 115.2±11.5 | 110.1±14.1 | 105.6±11.6 | 105.0±11.7 | 108.7±14.6 | 112.6±12.3 | 116.7±14.9 | 112.7±15.8 | 112.9±17.2 | 0.9362 |
Gr 3 | 118.6±10.0 | 114.0±14.3 | 107.4±10.2 | 106.5±14.6 | 109.5±13.6 | 118.1±13.6 | 124.8±17.3 | 115.4±13.0 | 116.5±14.0 | 0.0035 |
Gr 4 | 103.3±20.4 | 98.6±22.9 | 92.0±24.4 | 92.1±20.9 | 98.6±19.5 | 99.7±25.3 | 107.8±23.3 | 100.1±23.7 | 100.7±24.9 | 0.0572 |
%TLC (%) | ||||||||||
All | 109.2±11.8 | 106.6±12.6 | 104.8±12.9 | 104.4±12.2 | 105.5±12.3 | 110.0±12.9 | 112.4±13.2 | 105.8±12.3 | 105.3±12.3 | 0.7575 |
Gr 1 | 113.2±7.5 | 110.3±9.2 | 109.5±10.4 | 108.1±9.1 | 109.4±10.8 | 113.5±10.7 | 116.5±11.6 | 110.0±10.5 | 109.7±10.8 | 0.8201 |
Gr 2 | 110.7±12.6 | 109.6±12.1 | 106.5±13.2 | 106.0±12.3 | 107.1±12.8 | 114.1±14.0 | 113.3±13.7 | 106.6±13.1 | 105.8±13.0 | 0.7487 |
Gr 3 | 109.1±12.9 | 107.1±13.6 | 105.2±12.9 | 105.2±13.4 | 105.5±12.4 | 109.8±11.9 | 113.7±12.7 | 105.2±11.9 | 105.2±11.6 | 0.9982 |
Gr 4 | 103.5±12.3 | 99.2±12.5 | 97.9±12.8 | 98.2±12.2 | 100.0±12.0 | 102.5±12.3 | 106.1±13.3 | 101.4±12.9 | 100.8±13.0 | 0.4424 |
Data are expressed as mean±SD.
Gr 1, sIn<3.7 ng/mL; Gr 2, 3.7 ng/mL<sIn<9.9 ng/mL; Gr 3, sIn 10.0 ng/mL<sIn<22.4 ng/mL; Gr 4, 22.5 ng/mL<sIn.
*A single regression analysis was used to express chronological trends.
DLCO, diffusing capacity for carbon monoxide; Gr, group; sIn, serum indium level; TLC, total lung capacity; VC, volume capacity.