Chronological changes in the sIn, KL-6 and SP-D levels
| 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | p for trend* | |
|---|---|---|---|---|---|---|---|---|---|---|
| sIn | ||||||||||
| All | 8.6 (4.2) | 7.5 (4.7) | 8.0 (4.3) | 6.5 (5.1) | 4.4 (7.2) | 5.6 (5.4) | 5.8 (4.8) | 4.9 (5.2) | 4.9 (4.9) | 0.0019 |
| Gr 1 | 1.2 (2.4) | 1.0 (3.8) | 1.2 (3.3) | 0.8 (3.9) | 0.3 (4.7) | 0.6 (3.9) | 0.7 (2.9) | 0.6 (4.1) | 0.6 (3.4) | 0.0071 |
| Gr 2 | 6.0 (1.3) | 5.3 (1.3) | 5.7 (1.4) | 5.0 (1.4) | 3.4 (2.1) | 4.3 (1.5) | 4.3 (1.5) | 4.2 (1.5) | 4.0 (1.6) | <0.0001 |
| Gr 3 | 16.2 (1.3) | 14.1 (1.3) | 14.3 (1.4) | 12.7 (1.5) | 11.1 (1.5) | 11.8 (1.6) | 11.1 (1.5) | 8.8 (1.5) | 8.8 (1.5) | <0.0001 |
| Gr 4 | 46.4 (1.6) | 41.4 (1.7) | 41.0 (1.7) | 37.8 (1.7) | 33.5 (1.7) | 32.8 (1.8) | 33.6 (1.7) | 28.8 (1.7) | 27.9 (1.7) | <0.0001 |
| KL-6 | ||||||||||
| All | 448.0 (2.1) | 404.2 (2.0) | 376.2 (1.9) | 348.0 (1.9) | 352.2 (1.8) | 297.7 (1.8) | 289.9 (1.7) | 275.0 (1.8) | NA | <0.0001 |
| Gr 1 | 243.8 (1.5) | 222.4 (1.4) | 220.0 (1.4) | 227.1 (1.5) | 228.8 (1.4) | 205.8 (1.4) | 198.2 (1.4) | 187.9 (1.4) | NA | 0.0102 |
| Gr 2 | 383.8 (1.7) | 345.4 (1.7) | 327.3 (1.7) | 293.8 (1.6) | 316.7 (1.6) | 266.3 (1.5) | 253.7 (1.4) | 258.3 (1.6) | NA | 0.0002 |
| Gr 3 | 452.2 (2.0) | 418.0 (1.7) | 360.8 (1.7) | 328.2 (1.7) | 339.9 (1.7) | 259.3 (1.4) | 265.8 (1.5) | 239.7 (1.6) | NA | <0.0001 |
| Gr 4 | 952.2 (1.7) | 831.7 (1.7) | 770.8 (1.7) | 669.3 (1.7) | 624.4 (1.8) | 552.6 (1.8) | 528.5 (1.7) | 491.7 (1.8) | NA | <0.0001 |
| SP-D | ||||||||||
| All | 75.0 (1.8) | 65.7 (1.7) | 61.9 (1.9) | 53.5 (1.8) | NA | NA | 39.8 (2.3) | <0.0001 | ||
| Gr 1 | 57.1 (1.7) | 51.9 (1.6) | 49.4 (1.9) | 46.7 (1.8) | NA | NA | 34.4 (2.2) | 0.0049 | ||
| Gr 2 | 57.9 (1.6) | 52.1 (1.5) | 48.2 (1.7) | 42.7 (1.8) | NA | NA | 30.2 (2.2) | 0.0001 | ||
| Gr 3 | 73.5 (1.7) | 64.9 (1.6) | 57.8 (1.8) | 47.8 (1.6) | NA | NA | 33.7 (2.2) | <0.0001 | ||
| Gr 4 | 130.2 (1.6) | 106.3 (1.7) | 106.4 (1.6) | 85.7 (1.7) | NA | NA | 71.3 (1.9) | 0.0002 | ||
Data are expressed as geometric mean (geometric SD).
Gr 1, sIn<3.7 ng/mL; Gr 2, 3.7 ng/m<sIn<9.9 ng/mL; Gr 3, 10.0 ng/mL<sIn<22.4 ng/mL; Gr 4, 22.5 ng/mL<sIn.
*Test for chronological trend by applying single regression model.
Gr, group; NA, not available; sIn, serum indium concentration; SP-D, surfactant protein D.