Gene function prediction in biological pathways
| ELN | FBLN5 | MFAP4 | LTBP2 | ||||
|---|---|---|---|---|---|---|---|
| Biological pathways | p Value | Biological pathways | p Value | Biological pathways | p Value | Biological pathways | p Value |
| Collagen fibril organisation | 8.46E-25 | Extracellular structure organisation | 4.66E-12 | Extracellular structure organisation | 1.43E-21 | Regulation of leukocyte chemotaxis | 8.61E-22 |
| Extracellular structure organisation | 2.35E-18 | Extracellular matrix organisation | 4.66E-12 | Extracellular matrix organisation | 1.43E-21 | Cell-substrate adhesion | 2.18E-21 |
| Extracellular matrix organisation | 2.35E-18 | Regulation of systemic arterial blood pressure by hormone | 5.22E-11 | Negative regulation of androgen receptor signalling pathway | 4.33E-13 | Cell-matrix adhesion | 1.20E-17 |
| Blood vessel remodelling | 6.07E-17 | Response to amino acid stimulus | 2.38E-10 | TGFβ receptor signalling pathway | 1.20E-11 | TGFβ receptor signalling pathway | 1.28E-17 |
| TGFβ receptor signalling pathway | 1.60E-15 | Regulation of systemic arterial blood pressure by renin angiotensin | 8.97E-10 | Establishment of planar polarity of embryonic epithelium | 3.45E-11 | Positive regulation of leukocyte chemotaxis | 4.68E-17 |
| Transmembrane receptor protein serine/threonine kinase signalling pathway | 9.40E-14 | Chemokine-mediated signalling pathway | 1.02E-08 | Protein trimerisation | 4.22E-11 | Positive regulation of chemotaxis | 1.18E-16 |
| Striated muscle cell proliferation | 3.68E-13 | Regulation of blood pressure | 1.76E-08 | Response to prostaglandin E stimulus | 7.79E-11 | Regulation of protein processing | 1.29E-16 |
| Bone morphogenesis | 9.59E-13 | Response to amine stimulus | 1.81E-08 | Lung alveolus development | 1.60E-10 | Extracellular structure organisation | 2.17E-16 |
| Bone development | 1.06E-12 | Regulation of cell migration | 2.66E-08 | Transmembrane receptor protein serine/threonine kinase signalling pathway | 1.81E-10 | Extracellular matrix organisation | 2.17E-16 |
| Cardiac muscle cell proliferation | 2.04E-12 | Renal system process | 4.33E-08 | Collagen fibril organisation | 2.45E-10 | Regulation of leukocyte migration | 2.80E-16 |
| Cardiac muscle tissue growth | 4.78E-12 | Response to acid | 5.40E-08 | Respiratory tube development | 3.61E-10 | Negative regulation of TGFβ receptor signalling pathway | 1.29E-15 |
| Cardiac muscle cell apoptosis | 4.88E-12 | Regulation of blood volume by renin angiotensin | 1.36E-07 | Regulation of establishment of planar polarity | 3.74E-10 | Mononuclear cell migration | 4.75E-15 |
| Artery morphogenesis | 1.73E-11 | Regulation of cell motility | 1.57E-07 | Wnt receptor signalling pathway. Planar cell polarity pathway | 3.74E-10 | Negative regulation of transmembrane receptor protein serine/threonine kinase signalling pathway | 5.67E-15 |
| Negative regulation of transmembrane receptor protein serine/threonine kinase signalling pathway | 2.58E-11 | Positive regulation of angiogenesis | 2.13E-07 | Negative regulation of epithelial cell proliferation | 5.48E-10 | Vasculature development | 1.65E-14 |
| Artery development | 5.77E-11 | Collagen fibril organisation | 3.97E-07 | Cellular response to amino acid stimulus | 5.54E-10 | Angiogenesis | 1.68E-14 |
| Negative regulation of epithelial to mesenchymal transition | 6.24E-11 | Regulation of locomotion | 4.42E-07 | Lung development | 7.23E-10 | Positive regulation of behaviour | 3.02E-14 |
| Muscle cell apoptosis | 1.02E-10 | Regulation of cellular component movement | 4.75E-07 | Positive regulation of smoothened signalling pathway | 1.06E-09 | Regulation of cell migration | 4.55E-14 |
| Cartilage development involved in endochondral bone morphogenesis | 1.38E-10 | Negative regulation of transmembrane receptor protein serine/threonine kinase signalling pathway | 5.76E-07 | Establishment of planar polarity involved in neural tube closure | 2.35E-09 | Positive regulation of cell migration | 5.35E-14 |
| Cell-substrate adhesion | 1.46E-10 | Cellular response to organic nitrogen | 5.87E-07 | Cellular response to amine stimulus | 3.16E-09 | Blood vessel morphogenesis | 5.62E-14 |
| Negative regulation of cell morphogenesis involved in differentiation | 2.02E-10 | Response to organic nitrogen | 6.55E-07 | Positive regulation of filopodium assembly | 3.29E-09 | Blood vessel development | 6.98E-14 |
Overlap in gene function in biological pathways is indicated in bold.
ELN, elastin; FBLN5, fibulin-5; LTBP2, latent transforming growth factor β binding protein 2; MFAP4, microfibrillar associated protein 4; MGI, mouse genome informatics; TGFβ, transforming growth factor β.