Variable | Adjusted—IMD, age, sex, histology, year, CCI, timely GP referral (n=22 967, R2=5.77) | Adjusted—IMD, age, sex, histology, year, CCI, timely GP referral, stage, PS (n=22 967, R2=12.31) | Adjusted—IMD, age, sex, histology, year, CCI, timely GP referral, stage, PS, treatment (n=22 967, R2=27.97) | Adjusted—IMD, age, sex, histology, year, CCI, timely GP referral, stage, PS, treatment, timely 1st treatment (n=22 967, R2=28.74) | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR | 95% CI | p Value | OR | 95% CI | p Value | OR | 95% CI | p Value | OR | 95% CI | p Value | |||||
Deprivation quintile | <0.001 | 0.002 | 0.345 | 0.336 | ||||||||||||
1 (least deprived) | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||||||
2 | 0.87 | 0.76 | 1.00 | 0.054 | 0.87 | 0.76 | 1.01 | 0.073 | 0.88 | 0.75 | 1.04 | 0.130 | 0.88 | 0.75 | 1.04 | 0.137 |
3 | 0.86 | 0.75 | 0.98 | 0.026 | 0.87 | 0.75 | 1.00 | 0.054 | 0.90 | 0.77 | 1.06 | 0.222 | 0.90 | 0.76 | 1.05 | 0.180 |
4 | 0.80 | 0.70 | 0.91 | 0.001 | 0.83 | 0.72 | 0.95 | 0.005 | 0.94 | 0.81 | 1.09 | 0.410 | 0.94 | 0.81 | 1.09 | 0.394 |
5 (most deprived) | 0.74 | 0.66 | 0.84 | <0.001 | 0.77 | 0.68 | 0.88 | <0.001 | 0.87 | 0.75 | 1.00 | 0.056 | 0.87 | 0.75 | 1.00 | 0.053 |
Age group (years) | <0.001 | <0.001 | 0.115 | 0.040 | ||||||||||||
<60 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||||||
60–69 | 0.93 | 0.83 | 1.03 | 0.168 | 0.92 | 0.82 | 1.03 | 0.140 | 1.04 | 0.91 | 1.18 | 0.601 | 1.02 | 0.89 | 1.16 | 0.801 |
70–79 | 0.65 | 0.58 | 0.73 | <0.001 | 0.64 | 0.57 | 0.71 | <0.001 | 0.94 | 0.82 | 1.07 | 0.334 | 0.90 | 0.79 | 1.03 | 0.121 |
80+ | 0.35 | 0.31 | 0.41 | <0.001 | 0.34 | 0.30 | 0.39 | <0.001 | 0.88 | 0.74 | 1.03 | 0.119 | 0.84 | 0.71 | 1.00 | 0.048 |
Sex | <0.001 | <0.001 | <0.001 | <0.001 | ||||||||||||
Female | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||||||
Male | 0.74 | 0.69 | 0.80 | <0.001 | 0.73 | 0.67 | 0.79 | <0.001 | 0.72 | 0.66 | 0.79 | <0.001 | 0.71 | 0.65 | 0.78 | <0.001 |
Histology | <0.001 | <0.001 | <0.001 | <0.001 | ||||||||||||
NSCLC | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||||||
SCLC | 0.34 | 0.30 | 0.40 | <0.001 | 0.36 | 0.31 | 0.42 | <0.001 | 0.46 | 0.40 | 0.54 | <0.001 | 0.57 | 0.49 | 0.67 | <0.001 |
Other | 0.60 | 0.55 | 0.66 | <0.001 | 0.64 | 0.58 | 0.71 | <0.001 | 1.28 | 1.14 | 1.44 | <0.001 | 1.33 | 1.18 | 1.50 | <0.001 |
Year of Diagnosis | 0.082 | 0.204 | 0.009 | 0.009 | ||||||||||||
2006 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||||||
2007 | 1.06 | 0.95 | 1.18 | 0.301 | 1.05 | 0.94 | 1.18 | 0.351 | 1.02 | 0.90 | 1.15 | 0.765 | 1.00 | 0.88 | 1.13 | 0.954 |
2008 | 1.06 | 0.95 | 1.19 | 0.274 | 1.08 | 0.96 | 1.21 | 0.183 | 1.08 | 0.95 | 1.23 | 0.221 | 1.02 | 0.90 | 1.16 | 0.753 |
2009 | 1.19 | 1.04 | 1.36 | 0.010 | 1.16 | 1.01 | 1.33 | 0.036 | 0.83 | 0.71 | 0.98 | 0.025 | 0.80 | 0.68 | 0.93 | 0.005 |
Comorbidity score | 0.007 | 0.011 | <0.001 | <0.001 | ||||||||||||
0 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||||||
1–2 | 0.95 | 0.83 | 1.09 | 0.503 | 0.94 | 0.81 | 1.08 | 0.376 | 1.10 | 0.93 | 1.29 | 0.253 | 1.10 | 0.93 | 1.29 | 0.253 |
3+ | 0.84 | 0.66 | 1.07 | 0.158 | 0.79 | 0.61 | 1.03 | 0.077 | 0.96 | 0.72 | 1.28 | 0.787 | 0.96 | 0.72 | 1.29 | 0.807 |
Missing | 0.82 | 0.74 | 0.92 | <0.001 | 0.83 | 0.74 | 0.93 | 0.001 | 0.84 | 0.73 | 0.95 | 0.006 | 0.83 | 0.73 | 0.95 | 0.006 |
Unavailable | 0.94 | 0.82 | 1.07 | 0.324 | 0.97 | 0.85 | 1.11 | 0.659 | 1.37 | 1.17 | 1.60 | <0.001 | 1.38 | 1.18 | 1.61 | <0.001 |
Timely GP referral | <0.001 | <0.001 | <0.001 | <0.001 | ||||||||||||
No GP referral date | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||||||
FHA≤14 days | 1.44 | 1.32 | 1.58 | <0.001 | 1.40 | 1.28 | 1.53 | <0.001 | 1.16 | 1.05 | 1.29 | 0.004 | 1.14 | 1.03 | 1.26 | 0.015 |
FHA>14 days | 1.98 | 1.79 | 2.19 | <0.001 | 1.80 | 1.62 | 2.01 | <0.001 | 1.40 | 1.25 | 1.58 | <0.001 | 1.36 | 1.20 | 1.53 | <0.001 |
Stage | <0.001 | <0.001 | <0.001 | |||||||||||||
I | 1.00 | 1.00 | 1.00 | |||||||||||||
II | 0.38 | 0.29 | 0.50 | <0.001 | 0.48 | 0.35 | 0.68 | <0.001 | 0.49 | 0.35 | 0.69 | <0.001 | ||||
III | 0.13 | 0.11 | 0.16 | <0.001 | 0.29 | 0.23 | 0.36 | <0.001 | 0.30 | 0.24 | 0.38 | <0.001 | ||||
IV | 0.04 | 0.03 | 0.05 | <0.001 | 0.12 | 0.09 | 0.15 | <0.001 | 0.13 | 0.10 | 0.17 | <0.001 | ||||
Missing | 0.17 | 0.14 | 0.20 | <0.001 | 0.31 | 0.25 | 0.38 | <0.001 | 0.33 | 0.27 | 0.41 | <0.001 | ||||
Performance status | <0.001 | 0.001 | ||||||||||||||
0 | 1.00 | 1.00 | 1.00 | |||||||||||||
1–2 | 0.55 | 0.47 | 0.65 | <0.001 | 0.88 | 0.73 | 1.05 | 0.157 | 0.89 | 0.74 | 1.07 | 0.201 | ||||
3–4 | 0.18 | 0.14 | 0.24 | <0.001 | 0.59 | 0.43 | 0.81 | 0.001 | 0.61 | 0.44 | 0.83 | 0.002 | ||||
Missing | 0.45 | 0.38 | 0.54 | <0.001 | 0.73 | 0.60 | 0.90 | 0.002 | 0.72 | 0.59 | 0.88 | 0.002 | ||||
Type of treatment | <0.001 | <0.001 | ||||||||||||||
No treatment | 1.00 | 1.00 | ||||||||||||||
Surgery | 49.77 | 41.93 | 59.07 | <0.001 | 60.95 | 51.12 | 72.66 | <0.001 | ||||||||
Surgery + chemotherapy and/or radiotherapy | 33.00 | 26.99 | 40.34 | <0.001 | 40.47 | 32.96 | 49.69 | <0.001 | ||||||||
Chemotherapy | 3.25 | 2.71 | 3.91 | <0.001 | 4.19 | 3.47 | 5.05 | <0.001 | ||||||||
Chemotherapy + radiotherapy | 7.83 | 6.65 | 9.22 | <0.001 | 10.03 | 8.48 | 11.86 | <0.001 | ||||||||
Radiotherapy | 3.34 | 2.89 | 3.87 | <0.001 | 4.12 | 3.55 | 4.78 | <0.001 | ||||||||
Timely 1st treatment | <0.001 | |||||||||||||||
>31 days from diagnosis | 1.00 | |||||||||||||||
<31 days from diagnosis | 0.50 | 0.45 | 0.56 | <0.001 |
CCI score, Charlson Comorbidity Score; FHA, first hospital appointment; IMD, Index of Multiple Deprivation; NSCLC, non-small cell lung cancer; SCLC, small cell lung cancer.