Mean change (95% CI) in per cent predicted lung function measured at ages 1, 6 and 12 months, and 6, 12 and 18 years, associated with variables listed in the left hand column
| Change in % V'maxFRC/FEF25–75 associated with variable (univariate analysis) | Change in % V'maxFRC/FEF25–75 associated with variable (multivariable analysis) | Change in % V'maxFRC/FEF25–75 associated with variable (multivariable analysis including asthma history term) | |
|---|---|---|---|
| Maternal asthma | −8.2 (−15.1 to −1.3) p=0.020 | −9.8 (−16.5 to −3.0) p=0.005 | −8.9 (−16.5 to −1.3) p=0.023 |
| Flow limitation | −15.8 (−25.8 to −5.8) p=0.002 | −17.4 (−27.1 to −7.8) p<0.001 | −10.9 (−22.2 to +0.4) p=0.059 |
| Infant atopy | −11.3 (−19.4 to −3.2) p=0.006 | −12.6 (−20.5 to −4.7) p=0.002 | −11.9 (−20.4 to −3.4) p=0.006 |
| Maternal smoker during pregnancy | −6.2 (−12.9 to +0.4) p=0.069 | −8.1 (−14.6 to −1.6) p=0.015 | −8.2 (−15.8 to −0.5) p=0.036 |
| Male sex | −0.5 (−6.2 to +5.2) p=0.860 | −2.8 (−5.0 to +5.9) p=0.877 | −0.0 (−6.0 to +6.1) p=0.987 |
| Asthma ever | −7.3 (−13.5 to −1.0) p=0.022 | −6.0 (−12.2 to +0.3) p=0.061 |
Models in the second column were univariate, models in the third column were multivariable (excluding asthma ever, where data were missing in 81 individuals), while those in the fourth right hand column included all variables.