Airway wall area according to COPD status stratified by lumen diameter strata in SPIROMICS and the MESA COPD study
| MESA COPD | Lumen diameter strata in mm | ||||||
|---|---|---|---|---|---|---|---|
| >11.5 | >10.0 to 11.5 | >8.5 to 10.0 | >7.0 to 8.5 | >5.5 to 7.0 | >4.0 to 5.5 | >2.5 to 4.0 | |
| Unadjusted mean airway wall area in mm2 | |||||||
| COPD | 149.7 | 96.4 | 81.1 | 65.5 | 50.9 | 35.1 | 20.4 |
| No COPD | 144.4 | 92.6 | 78.5 | 62.0 | 46.8 | 32.7 | 19.7 |
| Difference (95% CI) p Value | 5.3 (−0.2 to 10.9) 0.06 | 3.8 (−0.6 to 8.4) 0.09 | 2.6 (−0.1 to 5.5) 0.06 | 3.5 (1.6 to 5.5) <0.001 | 4.1 (2.9 to 5.4) <0.001 | 2.4 (1.6 to 3.2) <0.001 | 0.7 (0.4 to 1.1) <0.001 |
| Mean airway wall area in mm2 adjusted for age, gender, height, race-ethnicity, smoking status, airway length, per cent emphysema−950HU, BMI-determined CT dose, and lung volume at CT | |||||||
| COPD | 141.9 | 93.6 | 78.2 | 64.9 | 50.6 | 34.9 | 22.0 |
| No COPD | 147.1 | 93.8 | 78.1 | 62.5 | 46.8 | 32.7 | 21.6 |
| Difference (95% CI) p Value | −5.2 (−10.1 to −0.2) p=0.04 | −0.2 (−4.4 to 4.3) p=0.9426 | 0.1 (−2.7 to 3.0) p=0.96 | 2.3 (0.5 to 4.2) p=0.01 | 3.8 (2.5 to 5.2) p<0.001 | 2.2 (1.3 to 3.0) p<0.001 | 0.4 (0.1 to 0.7) p=0.003 |
| Lumen diameter strata in mm | |||||||
| SPIROMICS | >11.5 | >10.0 to 11.5 | >8.5 to 10.0 | >7.0 to 8.5 | >5.5 to 7.0 | >4.0 to 5.5 | >2.5 to 4.0 |
| Unadjusted mean airway wall area in mm2 | |||||||
| COPD | 150.8 | 96.3 | 78.8 | 63.1 | 48.7 | 33.9 | 18.8 |
| No COPD | 145.6 | 94.1 | 77.6 | 61.6 | 46.2 | 32.1 | 18.6 |
| Difference (95% CI) p Value | 5.2 (2.5 to 8.0) <0.001 | 2.2 (−0.3 to 4.6) 0.08 | 1.2 (−0.2 to 2.7) 0.09 | 1.5 (0.5 to 2.4) 0.003 | 2.5 (1.8 to 3.2) <0.001 | 1.7 (1.4 to 2.1) <0.001 | 0.3 (0.1 to 0.5) <0.001 |
| Mean airway wall area in mm2 adjusted for age, gender, height, race-ethnicity, smoking status, airway length, per cent emphysema−950HU, BMI-determined CT dose, and lung volume at CT | |||||||
| COPD | 145.6 | 95.0 | 78.0 | 62.8 | 48.7 | 33.6 | 18.9 |
| No COPD | 146.1 | 94.5 | 78.2 | 62.8 | 47.0 | 32.2 | 18.6 |
| Difference (95% CI) p Value | −0.5 (−3.5 to 2.5) p=0.74 | 0.6 (−2.1 to 3.3) p=0.68 | −0.2 (−1.8 to 1.3) p=0.77 | 0.0 (−1.1 to 1.0) p=0.97 | 1.7 (0.9 to 2.5) p<0.001 | 1.4 (1.0 to 1.8) p<0.001 | 0.2 (0.1 to 0.4) p=0.01 |
Mean values and differences, along with 95% CI and p values were estimated using linear regression with generalised estimating equations.
BMI, body mass index; HU, Hounsfield units; MESA, Multi-Ethnic Study of Atherosclerosis; SPIROMICS Subpopulations and Intermediate Outcome Measures in COPD Study.