Results at 12 months after bilateral LVR coil treatment for patients classified as heterogeneous and homogeneous emphysema
| Visual CT assessment* | Digital CT assessment* | |||||
|---|---|---|---|---|---|---|
| (12 month follow-up group) | (12 month follow-up group) | |||||
| Heterogeneous (n=20) | Homogeneous (n=13) | p Value | Heterogeneous (n=16) | Homogeneous (n=17) | p Value | |
| ΔFEV1, L | +0.14±0.30 | +0.08±0.28 | 0.585 | +0.18±0.32 | +0.05±0.26 | 0.220 |
| ΔRV, L | −0.69±0.87 | −0.68±0.46 | 0.859 | −0.75±0.78 | −0.66±0.72 | 0.719 |
| Δ6MWD, m | +53.9±65.1 | +46.0±67.9 | 0.739 | +74.9±67.4 | +27.9±57.8 | 0.049 |
| ΔSGRQ, points | −12.9±15.1 | −7.3±8.7 | 0.187 | −12.4±13.9 | −9.1±12.9 | 0.491 |
Results are given as mean±SD change from baseline. Heterogeneity and homogeneity were assessed by both a visual CT assessment (a 4-point qualitative score of the degree of tissue destruction where a difference of ≤1 point for both lungs was regarded as homogeneous) and a digital CT assessment (where the software calculated the percentage area of destruction at –950 Hounsfield Units; a difference of ≤25% in destruction for both lungs was regarded as homogeneous).
6MWD, 6-min walking distance; FEV1, forced expiratory volume in 1 s; LVR, lung volume reduction; RV, residual volume; SGRQ, St George's Respiratory Questionnaire total score.
*p<0.05 for all end-points compared to baseline.