COPD matched subjects stable/exacerbation
| Matched COPD Subjects (n = 36) | |||
|---|---|---|---|
| Demographic | Stable | Exacerbation | P value |
| FEV1, a % predicted | 53 ± 23 | 48 ± 19 | <0.001 |
| MRC Score | 5.00, 1.25 | 5.00, 1.25 | <0.16 |
| Breathing Score | 3.00, 0.00 | 4.00, 1.00 | <0.006 |
| ADL Score | 3.00, 1.00 | 4.00, 2.00 | <0.014 |
| Sputum Amount Texture Colour | 2.00, 2.00 1.94, 0.33 3.00, 1.00 | 3.00, 2.25 2.06, 0.41 4.00, 1.50 | <0.001 <0.05 <0.001 |
| Salivary Biomarkers b | |||
| CRP, ng/ml | 1.61, 1.10 | 7.35, 10.04 | <0.001 |
| PCT, ng/ml | 0.09, 0.06 | 0.50, 0.71 | <0.001 |
| NE, ng/ml | 128, 190 | 769, 1680 | <0.001 |
a, Mean ± standard deviation
b, Median, inter-quartile range
COPD = Chronic Obstructive Pulmonary Disease; FEV1 = Forced Expiratory Volume in 1 second; MRC = Medical Research Council; ADL = Activity of Daily Living; CRP = C-Reactive Protein; PCT = Procalcitonin; NE = Neutrophil Elastase.
P values represent the difference between stable and exacerbation phase.