| All | Sputum eosinophils <3% | Sputum eosinophils >3% | p value | |
|---|---|---|---|---|
| Number observations | n = 165 | n = 114 (69%) | n = 54 (31%) | |
| Age (years) | 56.2 ± 13.4 | 57.4 ± 13.75 | 53.5 ± 12.2 | 0.081 |
| Gender Male n (%) Female n (%) | 81 (49.1%) 84 (50.9%) | 53 (46.5%) 61 (53.5%) | 28 (54.9%) 23 (45.1%) | - |
| FEV1 (Litres) | 2.39 ± 0.85 | 2.46 ± 0.87 | 2.23 ± 0.79 | 0.12 |
| FEV1% predicted | 80.5 ± 20.7 | 83.54 ± 19.4 | 73.7 ± 23.2 | 0.005* |
| FVC (Litres) | 3.46 ± 1.03 | 3.49 ± 1.06 | 3.36 ± 0.95 | 0.46 |
| FVC% predicted | 95.1 ± 18.8 | 96.9 ± 17.5 | 91.0 ± 21.09 | 0.062 |
| FEV1/FVC | 68.7 ± 9.9 | 70 ± 9.8 | 65.7 ± 9.4 | 0.008* |
| Body-mass index (Kg/m2)† | 28.6 ± 5.1 | 28.8 ± 4.0 | 26.9 ± 3.0 | 0.54 |
| History of smoking (Pack-years) Median (range) | 0 (0,20) | 0. (0,20) | 0 (0,15) | 0.87† |
| Daily inhaled corticosteroid dose (Becolmetasone diproprionate equivalent [mcg/day]) Median (range) | 400 (0, 3200) | 400 (0, 3200) | 800 (0, 3200) | 0.05† |
| Oral Prednisolone Median (range) | 0 (0, 20) | 0 (0, 15) | 0 (0, 20) | - |
| Juniper ACQ# score | 1.4 ± 1.0 | 1.1 ± 0.9 | 1.9 ± 1.2 | <0.001* |
| Exhaled nitric oxide FeNO at 50ml flow (ppb) Geometric mean (95% CI) | 25.7 (22.9, 28.8) | 20.0 (17.8, 22.9) | 44.7 (35.5, 56.23) | <0.001* |
| Sputum differential eosinophil count % Geometric mean (95% CI) | 1.24 (0.95, 1.62) | 0.47 (0.39, 0.55) | 11.0 (8.3, 14.13) | <0.001* |
| Blood eosinophils (x109/L) Geometric mean | 0.24 (0.22, 0.28) | 0.19 (0.18, 0.21) | 0.43 (0.36, 0.5) | <0.001* |
Arithmetic mean values reported as mean unless specified
± Standard deviation
Geometric means are reported with a 95% Confidence Interval (CI)
The difference between means compared with t-test unless specified with †
# Juniper Asthma Control Questionnaire- A validated questionnaire providing a numerical assessment of asthma control over the preceding 7 days. The mean score ranges from 0 (fully controlled) to 6 (poorly controlled)
† Mann-Whitney U
*p < 0.05
FEV1- Forced expiratory volume in one second
FVC- Forced vital capacity
ppb- Parts per billion