Change in peak CPET variables and inspiratory capacity at isotime with and without beta-blockade in 46 subjects with and without COPD
| COPD (n = 25) | No COPD (n = 21) | |||
|---|---|---|---|---|
| β-blocker | ON | OFF | ON | OFF |
| Peak VO2 | 17.4 (3.5) | 17.8 (3.5) | 19 (6.1) | 18.9 (6.3) |
| Peak VO2/kg | 1.43 (0.31) | 1.46 (0.32) | 1.58 (0.51) | 1.56 (0.47) |
| Peak Work | 102# (27) | 106 (27) | 113 (30) | 110 (31) |
| Peak VE/VO2 | 37.2 # (4.9) | 38.7 (5.7) | 39.2 (5.3) | 39.3 (5.1) |
| Peak VE/VCO2 | 33.9 (3.3) | 34.6 (3.9) | 34.6 (3.9) | 35.3 (3.8) |
| Peak O2 Pulse | 12.6 ## (2.6) | 10.9 (2.4) | 14 ## (3.7) | 11.9 (3.1) |
| Peak HR | 114 ## (15) | 134 (17) | 114 ## (25) | 132 (19) |
| Δ IC isotime (ml) | -142 ~ | -188 ~ | -15 | -16 |
~ p < 0.05 COPD vs. no COPD, # p < 0.05 on vs. off beta-blockers and ## p < 0.01 on vs. off beta-blockers