Cardiac output, haematocrit and arterial pH in the three sheep groups over 24 h
| Parameter | Group | Baseline | 3 | 6 | 9 | 12 | 15 | 18 | 21 | 24 |
|---|---|---|---|---|---|---|---|---|---|---|
| Cardiac output | Control | 5.37±0.1 | 6.07±0.4 | 5.94±0.2 | 6.14±0.3 | 5.69±0.4 | 5.50±0.4 | 5.77±0.6 | 6.15±0.6 | 6.10±0.5 |
| Lower dose | 5.64±0.4 | 6.10±0.5 | 6.65±0.4 | 7.05±0.5 | 7.25±0.6 | 6.55±0.6 | 6.49±0.5 | 6.11±0.3 | 5.95±0.5 | |
| Higher dose | 5.25±0.2 | 6.04±0.5 | 6.24±0.5 | 6.54±0.6 | 6.04±0.5 | 6.03±0.6 | 6.00±0.4 | 5.45±0.2 | 5.56±0.3 | |
| Haematocrit | Control | 26.6±0.7 | 30.3±0.9 | 30.3±1.1 | 29.1±1.0 | 29.3±1.3 | 30.6±1.6 | 29.5±0.8 | 27.5±0.3 | 28.0±0.5 |
| Lower dose | 25.3±1.0 | 26.1±1.3* | 28.3±1.5 | 26.7±1.1 | 27.3±1.2 | 28.3±0.8 | 28.9±3.0 | 25.8±1.4 | 25.5±1.5 | |
| Higher dose | 28.4±0.4 | 29.0±0.0 | 30.8±0.5 | 30.0±0.0 | 30.8±1.7 | 29.3±0.6 | 29.5±0.3 | 29.0±0.4 | 28.7±0.9 | |
| Arterial pH | Control | 7.50±0.01 | 7.55±0.02 | 7.56±0.03 | 7.54±0.03 | 7.50±0.04 | 7.50±0.04 | 7.52±0.02 | 7.53±0.03 | 7.53±0.03 |
| Lower dose | 7.48±0.02 | 7.58±0.02 | 7.56±0.01 | 7.51±0.02 | 7.52±0.01 | 7.50±0.02 | 7.47±0.05 | 7.44±0.05 | 7.47±0.02 | |
| Higher dose | 7.50±0.01 | 7.57±0.02 | 7.55±0.01 | 7.52±0.02 | 7.52±0.01 | 7.50±0.00 | 7.48±0.04 | 7.50±0.07 | 7.53±0.02 |
Data are expressed as mean±SEM.
*p=0.02 compared with control sheep by ANCOVA. Control: n=8 for 0–12 h; n=7 for 15 h; n=6 for 18–24 h. Lower dose: n=7 for 0–18 h; n=6 for 21 24 h. Higher dose: n=4 for 0–21 h; n=3 for 24 h.