Secondary outcomes measured during procedures, medications and complications
| Group A: EBUS-centred (n=80) | Group B: EUS-centred (n=80) | p Value | |
|---|---|---|---|
| Total procedure time, mean (SD), min:s | 38:3 (7:13) | 39:4 (9:30) | 0.422 |
| EBUS procedure time, mean (SD), min:s | 23:5 (5:39) | 18:1 (6:6) | <0.0001 |
| EUS procedure time, mean (SD), min:s | 6:4 (5:15) | 13:5 (8:3) | <0.0001 |
| No. of nodal stations, mean (SD) | 3.5 (0.9) | 3.7 (1.2) | 0.232 |
| No. nodal stations by EBUS-TBNA, mean (SD) | 3.0 (0.8) | 2.5 (0.8) | 0.000 |
| No. nodal stations by EUS-FNA, mean (SD) | 0.9 (0.9) | 1.9 (1.2) | <0.0001 |
| No. of aspirations, mean (SD) | 9.6 (2.9) | 10.2 (3.6) | 0.320 |
| No. of aspirations by EBUS-TBNA, mean (SD) | 8.1 (2.4) | 6.1 (2.4) | <0.0001 |
| No. of aspirations by EUS-FNA, mean (SD) | 1.6 (1.8) | 4.1 (2.8) | <0.0001 |
| Midazolam, mean (SD), mg | 3.0 (0.6) | 3.0 (0.6) | 0.670 |
| Fentanyl, mean (SD), μg | 50.8 (10.6) | 51.7 (7.4) | 0.809 |
| Lidocaine, mean (SD), mg | 442.3 (61.2) | 431.3 (53.4) | 0.228 |
| Mean SBP, mean (SD), mm Hg | 144.2 (20.1) | 145.9 (22.8) | 0.629 |
| Mean SBP during first procedure, mean (SD), mm Hg | 138.8 (22.8) | 141.1 (22.2) | 0.512 |
| Mean SBP during EBUS time, mean (SD), mm Hg | 138.8 (22.8) | 151.4 (25.5) | 0.001 |
| Mean SBP during EUS time, mean (SD), mm Hg | 149.6 (25.4) | 141.1 (22.2) | 0.026 |
| Maximum SBP, mean (SD), mm Hg | 171.1 (27.4) | 174.9 (31.0) | 0.422 |
| Maximum SBP during first procedure, mean (SD), mm Hg | 157.4 (27.5) | 151.2 (28.1) | 0.160 |
| Maximum SBP during EBUS time, mean (SD), mm Hg | 157.4 (27.5) | 170.7 (30.8) | 0.004 |
| Maximum SBP during EUS time, mean (SD), mm Hg | 156.7 (28.4) | 151.2 (28.1) | 0.213 |
| Mean HR, mean (SD), n/min | 82.9 (16.0) | 82.6 (12.5) | 0.891 |
| Mean HR during first procedure, mean (SD), n/min | 80.0 (18.8) | 77.4 (13.2) | 0.314 |
| Mean HR during EBUS time, mean (SD), n/min | 80.0 (18.8) | 88.8 (18.5) | 0.003 |
| Mean HR during EUS time, mean (SD), n/min | 84.5 (17.0) | 77.4 (13.2) | 0.003 |
| Mean SaO2, mean (SD), % | 97.7 (1.5) | 98.3 (2.4) | 0.084 |
| Mean SaO2 during first procedure, mean (SD), % | 98.1 (1.6) | 98.8 (1.2) | 0.002 |
| Mean SaO2 during EBUS time, mean (SD), % | 98.1 (1.6) | 97.9 (1.6) | 0.590 |
| Mean SaO2 during EUS time, mean (SD), % | 97.9 (1.9) | 98.8 (1.2) | 0.001 |
| Number of coughs, median (IQR) | 95.5 (100) | 89.5 (115.5) | 0.921 |
| Coughs during EBUS time, median (IQR) | 40.5 (87) | 58.5 (86) | 0.226 |
| Coughs during EUS time, median (IQR) | 6 (14) | 5 (15) | 0.434 |
| Hypoxic event, no. of patients | 17 | 19 | 0.705 |
| Irritable movement, no of patients | 3 | 2 | 1.000 |
| Major complications | |||
| Pneumomediastinum | 0 | 1 | 1.000 |
| Minor complications | |||
| Mediastinal or perinodal bleeding | 5 | 7 | 0.548 |
| Bleeding by EBUS-TBNA | 3 | 0 | 0.245 |
| Bleeding by EUS-FNA | 2 | 7 | 0.167 |
| Hiccup after procedure | 2 | 1 | 1.000 |
| Chest pain after procedure | 0 | 1 | 1.000 |
EBUS-TBNA, endobronchial ultrasound-guided transbronchial needle aspiration; EUS-FNA, endoscopic ultrasound-guided fine needle aspiration; HR, heart rate; SaO2, oxygen saturation; SBP, systolic blood pressure.