Symptomatology and hospitalisation rate associated with viral infection in lung transplant recipients (n=174)
| Picornavirus (n=105) | Coronavirus (n=22) | Influenza (n=18) | RSV (n=11) | HMpV (n=8) | PIV (n=6) | Bocavirus (n=2) | Adenovirus (n=2) | |
|---|---|---|---|---|---|---|---|---|
| New respiratory symptoms | 67.6 (57.8 to 76.4) | 72.7 (49.8 to 89.3) | 88.8 (65.3 to 98.6) | 90.9 (58.7 to 99.8) | 75.0 (34.9 to 96.8) | 100 (54.1 to 100) | 50.0 (1.3 to 98.7) | 100 (15.8 to 100) |
| Fever | 14.3 (8.22 to 22.5) | 13.6 (2.9 to 34.9) | 61.1 (35.7 to 82.7) | 9.1 (0.2 to 41.3) | 12.5 (0.3 to 53.6) | 0 (0 to 45.9) | 0 (0 to 84.2) | 50.0 (1.3 to 98.7) |
| Rhinorrhoea | 42.8 (33.2 to 52.9) | 50.0 (28.2 to 71.8) | 66.7 (40.9 to 86.5) | 81.8 (48.2 to 97.7) | 75.0 (34.9 to 96.8) | 33.3 (4.3 to 77.7) | 50.0 (1.3 to 98.7) | 0 (0 to 84.2) |
| Cough | 41.9 (32.3 to 51.9) | 36.4 (17.2 to 59.3) | 61.1 (35.7 to 82.7) | 72.7 (39.02 to 94.0) | 50.0 (15.7 to 84.3) | 100 (54.1 to 1) | 50.0 (1.3 to 98.7) | 100 (15.8 to 100) |
| Dyspnoea | 36.2 (27.0 to 46.1) | 31.8 (13.9 to 54.9) | 44.4 (21.5 to 69.2) | 36.4 (10.9 to 69.2) | 25.0 (3.2 to 65.1) | 83.3 (35.9 to 99.6) | 50.0 (1.3 to 98.7) | 100 (15.8 to 100) |
| Thoracic pain | 6.6 (27.2 to 13.3) | 18.2 (51.9 to 40.3) | 22.2 (6.4 to 47.6) | 9.1 (0.2 to 41.3) | 0 (0 to 36.9) | 16.7 (0.4 to 64.1) | 0 (0 to 84.2) | 100 (15.8 to 100) |
| Sputum | 23.8 (16.0 to 33.1) | 18.2 (51.9 to 40.3) | 44.4 (21.5 to 69.2) | 45.5 (16.7 to 76.6) | 50.0 (15.7 to 84.3) | 83.3 (35.9 to 99.6) | 50.0 (1.3 to 98.7) | 100 (15.8 to 100) |
| Myalgia | 7.6 (3.3 to 14.4) | 4.5 (0.1 to 22.8) | 27.8 (9.7 to 53.5) | 27.3 (6.0 to 61.0) | 12.5 (0.3 to 52.7) | 0 (0 to 45.9) | 0 (0 to 84.2) | 50.0 (1.3 to 98.7) |
| Fatigue | 31.4 (22.7 to 41.2) | 22.7 (7.8 to 45.4) | 55.6 (30.8 to 78.5) | 63.6 (30.8 to 89.1) | 6.3 (24.5 to 91.5) | 66.7 (22.3 to 95.7) | 50.0 (1.3 to 98.7) | 50.0 (1.3 to 98.7) |
| Sore throat | 13.3 (7.5 to 21.4) | 13.6 (2.9 to 34.9) | 55.6 (30.8 to 78.5) | 45.5 (16.7 to 76.6) | 0 (0 to 36.9) | 50.0 (11.8 to 88.2) | 0 (0 to 84.2) | 0 (0 to 84.2) |
| Sum of symptoms: mean (SD) | 2.2 (2.3) | 2.1 (2.0) | 4.4 (3.0) | 3.9 (2.4) | 2.9 (2.5) | 4.3 (1.6) | 2.5 (3.5) | 5.5 (2.1) |
| Hospitalisation | 18.1 (11.3 to 26.8) | 22.7 (7.8 to 45.3) | 44.4 (21.5 to 69.2) | 0 (0 to 28.5) | 12.5 (0.1 to 52.7) | 50 (11.8 to 88.2) | 0 (0 to 84.2) | 100 (15.8 to 100) |
| FEV1 loss (ref: pre-infection period, mL (SD)) | −103 (259) | −22 (279) | −177 (121) | −71 (415) | −251 (220) | −181 (115) | −180 (56) | – |
| Acute rejection after infection, n (days) | 2 (90 days) | 1 (120 days) | 1 (150 days) | – | – | – | – | – |
All values expressed as percentages with 95% CI or mean with SD.
HMpV, human metapneumovirus; PIV, parainfluenza virus; RSV, respiratory syncytial virus.