Clinical features of infants with NBS-diagnosed CF undergoing CT at 1 year of age
| Features | Value |
|---|---|
| N (% boys) | 65 (48) |
| Age at diagnosis, weeks* | 3.4 (3.0−4.4) |
| Pancreatic insufficiency, n (%) | 61 (94) |
| Meconium ileus, n (%) | 7 (11) |
| Delta F508†, n (%) | 58 (89) |
| Age at time of test, weeks | 52.7 (4.7) |
| Somatic growth | |
| Weight, z score‡ | 0.34 (0.10) |
| Length, z score‡ | 0.49 (0.97) |
| Body mass index, z score‡ | 0.09 (0.84) |
| Before 1 year CT assessments | |
| Respiratory symptoms, ever: | |
| Wheeze, physician-diagnosed | 22 (34) |
| Crackles, physician-diagnosed | 7 (11) |
| Bacterial growth on cough swab, ever§ | |
| Pseudomonas aeruginosa¶ | 20 (31) |
| Other significant bacterial growth** | 24 (37) |
| No growth†† | 21 (32) |
Results expressed as mean (SD) or n (%) unless otherwise stated.
*Median (IQR).
†Homozygous or heterozygous.
‡Calculated according to Cole et al.26
§Based on the presence of bacteria ever isolated in the first year.
¶Definition of colonisation according to Lee et al27; only 2/65 (3%) infants had any evidence of Pseudomonas aeruginosa (PsA) on bronchoalveolar lavage or cough swab within 5 days of the CT scan.
**Significant bacterial growth consisted of those who had methicillin-sensitive or methicillin-resistant Staphylococcus aureus (MSSA or MRSA, respectively), Haemophilus influenza (HI), Stenotrophomonas maltophilia, Acromobacter xylosidans or Aspergillus fumigatus with no previous growth of PsA.
††No bacterial growth consisted of those with isolation of coliforms and upper respiratory tract flora only.
CF, cystic fibrosis; NBS, newborn screened.